Purpose: to establish the histological features of bone tissue remodeling when using BIOS and to consider the features of bone tissue restoration in static, dynamic, and compression types of blocking. Object and research methods. The study included 80 patients with diaphyseal fractures of the femur and tibia after removal of BIOS fixators with static, compression, and dynamic pin locking. Pathomorphological examination of tissues was performed in 50 cases: areas of the former fracture, fabric around the retainer and screws. The average age of the patients was 45.7±5.9 years, who were operated on to remove the BIOS. Among the patients, 58% were women. Only patients with fracture union without negative consequences, such as fracture of the fixator, delayed consolidation or nonunion, infection, etc., were included in the histological study. The results. Around metal fasteners, the density of bone tissue increases statistically significantly after 18 months, especially in the areas where the screws and pins are located, which complicates the removal of the intramedullary rod. Destructive changes in the cortex were noted. Thus, the data of the histological study proved that the removal of BIOS in patients may be expedient in the early days after fracture union, as the formation of large foci of bone tissue in the region of the intramedullary blocked rod will significantly complicate the removal of the fixator. Clinical and radiological studies have shown that the highest percentage of fracture healing was observed in BIOS osteosynthesis with compression locking of the pin (76%).