Objective: to investigate the efficacy and safety of 12 weeks of Intelaria complex intake (1 capsule twice a day) in patients with mild cognitive impairment (MCI) of vascular genesis. Object and methods. Two comparable groups of 30 patients each with mild cognitive impairment (Montreal Cognitive Assessment Scale (MоCA) less than 26 points) and neuroimaging signs of cerebral microangiopathy were formed. Both groups took medications to correct cardiovascular disease, and patients in the first group also took the Intelaria complex. Patients were invited for scheduled visits in 4, 8, 12, 18 and 24 weeks. The cognitive state of patients was determined using the MoCA scale, and the psycho-emotional condition was determined using the Hospital Anxiety and Depression Scale. Results. A 12-week intake of the Intelaria complex in patients with vascular MCI is associated with a significant improvement in cognitive function (due to optimization of visual-constructive and executive domen) and a tendency to reduce the frequency of anxiety disorders. These positive effects on the cognitive and psycho-emotional conditions are stable and last at least for the next 12 weeks after the end of the drug. Conclusion. The complex Intelaria (1 capsule twice a day) has a stable positive effect on the cognitive and psycho-emotional state in patients with vascular MCI.