Objective: Determining the relationship between clinical and electrophysiological features of spasticity in patients with multiple sclerosis. Materials and methods. We examined 100 patients with multiple sclerosis with spasticity. The Modified Ashworth Scale was used to quantify the severity of changes in muscle tone. Electroneuromyography was performed on a «Nihon Kohden» device using standard non-invasive stimulation techniques in the upper and lower extremities. Results. The level of average spasticity in patients on the Modified Ashworth Scale ranged from 0.4 to 3.0 points. The level of spasticity of individual muscle groups was found to be significantly different in the three groups of different types of multiple sclerosis. The level of total spasticity in patients with multiple sclerosis was statistically significantly increased in patients with severe disability and had a direct mean correlation with the degree of Expanded Disability Status Scale (rs=0.649; p<0.05). Assessment of the function of n. medianus and n. tibialis motor fibers revealed significant changes in M-amplitude. Conclusions. The highest values of mean spasticity are observed in patients with secondary-progressive multiple sclerosis, pyramidal and bowel/bladder functional systems have the strongest correlation with the level of total spasticity (rs=0.712 and 0.666; p<0.05, respectively). Among the muscle groups of the lower extremities, the average score of spasticity is the highest in the knee extensors in secondary-progressive multiple sclerosis patients — 2.49±0.19 points, and the lowest in patients with relapsing-remitting multiple sclerosis for foot flexors — 1.08±0.06 (p<0.01). The main electrophysiological indicator of early manifestations of muscle spasticity of the upper and lower extremities in patients with multiple sclerosis is a decrease in the amplitude of the M-response (p<0.01).