Aim: to establish the prognostic value of risk factors associated with the peculiarities of knee osteoarthritis in relation to the long-term results of unicompartmental knee replacement. Materials and methods. Long-term results of unicompartmental knee replacement in 99 patients with medial knee osteoarthritis were analyzed — 26 (26.26%) men and 73 (73.74%) women. The average age was 63.78±8.21 years. According to the results of the Oxford Knee Score questionnaire, 4 groups were formed. Group 1 included 62 (62.63%) patients without progression of knee osteoarthritis in long-term period. Mild manifestations of knee osteoarthritis were found in 23 (23.23%) patients of group 2, moderate — in 10 (10.10%) examined 3 groups, and 4 (4.04%) patients of group 4 recorded severe manifestations of the disease. The average result of treatment in the remote period was 37.65±7.89. Risk factors such as pathogenetic variants of osteoarthritis, previous joint surgery, stage, duration of the disease before surgery and duration of the postoperative period were assessed. «Statistica 13» was used for statistical analysis. Results. It was found that the duration of the disease before surgery ≤5 years (odds ratio (OR) 2.70; 95% confidence interval (CI) 1.11–6.58; p=0.02) and the duration of the postoperative period ≤5 years (OR 5.01; 95% CI 1.90–13.20; p=0.0007) increase the chances of no progression of knee osteoarthritis in the long term. Instead, the presence of previous operations in the knee joint (OR 12.0; 95% CI 1.15–125.52; p=0.02) are associated with the progression of knee osteoarthritis. Conclusion. The high prognostic value of risk factors associated with the peculiarities of knee osteoarthritis in assessing the long-term results of unicompartmental knee replacement has been proven.