Objective — to assess the dynamics of the quality of life in patients with coronary heart disease with impaired metabolism of vitamin D and homocysteine after coronary artery bypass grafting (CABG). Materials and methods. CABG was performed on 126 patients with coronary heart disease. Patients completed the SF-36 quality of life questionnaire upon admission to the department and after 6 and 12 months after surgery. Results. In patients after CABG who received additional metabolic therapy, as a rule, there were no relapses of angina pectoris, improvement in the quality of life persisted both in the early and long-term periods (up to 3 years of follow-up). In patients with recurrent angina pectoris after CABG, both in the preoperative and in the long-term periods, the quality of life indicators significantly differed from the level of ideal health. The most significant impairments were indicators of mental health, physical functioning and social relations sphere. Conclusions. In patients after CABG, the SF-36 questionnaire can provide a reliable and sensitive assessment of quality of life. Correction of metabolic disorders and lipid metabolism disorders is essential for patients who have undergone surgery on the heart vessels. Correction of metabolic disorders should be started immediately after surgery.