Dyslipidemia and hypothyroidism are important risk factors for coronary heart disease. Aim: comparative assessment of the effect of dyslipidemia and hypothyroidism on the morphofunctional condition of the heart. Material and methods. The study included the results of examinations of 63 patients, 42 men and 21 women. All patients had coronary heart disease and were divided into two groups: dyslipidemia — 47 (75%) and hypothyroidism — 16 (25%) patients. Anamnestic data were collected from all patients, biochemical analysis of blood (lipid profile, blood sugar), electrocardiogram, echocardiogram were performed, and the results of coronary angiography were evaluated by SYNTAX score. These indicators were evaluated and compared in the initial and 1-year follow-up period after basic treatment in accordance with international classifications. The obtained results were developed in IBM Statistics SPSS-26 program; p<0.05 was considered statistically accurate. Results. Dyslipidemia causes more damage to the coronary arteries than hypothyroidism. Thus, the number of localizations in the coronary arteries with more than 50% of the damage and the number of damaged vessels was higher in the dyslipidemia group than in the hypothyroidism group. Dyslipidemia can be considered a more dangerous risk factor than hypothyroidism.