Purpose: to investigate the effectiveness of a complex approach in the treatment of patients with choledocholithiasis complicated by concomitant liver cirrhosis. Object and research methods. A prospective analysis of the treatment of 37 patients with choledocholithiasis with accompanying liver cirrhosis, who were treated in the Kyiv City Clinical Hospital of Emergency Care from 2019 to 2023, was conducted. The scope of medical care, the course and effectiveness of the treatment were characterized. The results. According to the results of a prospective analysis of the treatment of patients with choledocholithiasis complicated by concomitant liver cirrhosis, it was found that the applied complex therapeutic algorithm contributed to the improvement of the general condition of patients, the reduction of dyspeptic manifestations, astheno-vegetative disorders and the severity of pain syndrome, the resolution of the symptoms of mechanical jaundice, the normalization of laboratory and biochemical indicators, stabilization of blood coagulation profile. Improvement of the synthetic and detoxification function of the liver, normalization of hepatic hemodynamics and activation of regenerative processes were noted. Conclusion. The use of a complex interdisciplinary approach in the treatment of choledocholithiasis against the background of liver cirrhosis reveals a positive effect on the clinical and biochemical indicators of the course of the disease with positive dynamics of the resolution of the symptomatic picture of both the main and accompanying pathology, which indicates the effectiveness of the selected approach and the optimality of its integration into standardized algorithms of targeted treatment of patients with choledocholithiasis, complicated liver cirrhosis.