Physical properties and endogenous intoxication of oral fluid in rapid diagnosis of personalized cardiometabolic risk | Ukrainian Medical Journal

The search for simple, rapid and non-invasive markers for timely prevention of cardiovascular events and verification of cardiometabolic risk is highly relevant due to prolonged stress factor in residents of frontline regions. Purpose of the study: to assess the informativeness of examining the physical properties and the degree of endogenous intoxication of oral fluid as a non-invasive express method for determining cardiometabolic risk in residents of frontline regions. Materials and methods of the study. The study involved 51 people divided into 3 groups depending on their cardiometabolic risk level: the main group — 19 patients with metabolic-associated disorders and high risk according to SCORE2; comparison group — individuals with subclinical risk; and control (12 conditionally healthy individuals). Salivation rate, viscosity and pH were determined according to generally accepted methods. The level of endogenous intoxication was assessed by the method of wedge-shaped dehydration with a crystallographic scoring of facies. Results. In patients of the main group, significant inhibition of salivary gland function was detected under the influence of both metabolic disorders and in combination with chronic stress — in the main group, a critical decrease in salivation rate, a mirror increase in viscosity and a shift of the pH to the acidic side were recorded. Facies architecture analysis allowed determining the presence of a high degree of endogenous intoxication (the appearance of chaotic conglomerates and dark pigmentation in the central zone) in almost 80.0% of individuals with high cardio-metabolic risk. Conclusion. The study of physical parameters and endogenous intoxication in oral fluid is a simple, highly informative and non-invasive diagnostic method that allows objectively assessing the cumulative impact of metabolic disorders and prolonged stress in residents of frontline areas for timely prediction of cardiometabolic risk.

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