Investigation of the problem of non-ossifying fibroma in children | Ukrainian Medical Journal

The purpose of this study was to analyze scientific data on the problem of disorders of bone morphogenesis in children, in particular, unsynthesized bone fibrosis, as well as modern methods of diagnosis and treatment of this disease in the light of the latest scientific advances. The latest data of scientists from leading clinics in the world were analyzed, which describe various forms of fibrous lesions of the skeleton in children of different age groups. The long-term results of observations of such patients after 40 years of age, in whom fibrous lesions of the skeletal bones were observed in childhood, were studied. A boy with fibrous lesions of the cortical layer of the knee joint bones and a girl with extensive fibrous lesions of the distal femoral metaphysis, which led to a closed pathological bone fracture, were examined. Surgical treatment, osteosynthesis, marginal resection of the tumor, bone grafting, and histological examination were performed.

References

1. Levine M.A. (2012) Assessing bone health in children and adolescents. Ind. J. Endocrinol. Metabol., 16(Suppl. 2): S205–S212. doi.org/10.4103/2230-8210.104040.
2. Salhotra A., Shah H.N., Levi B., Longaker M.T. (2020) Mechanisms of bone development and repair. Nature reviews. Molecular cell biology, 21(11): 696–711. doi.org/10.1038/s41580-020-00279-w.
3. O’Flynn O’Brien K.L., Varghese A.C., Agarwal A. (2010) The genetic causes of male factor infertility: a review. Fertility and sterility, 93(1): 1–12. doi.org/10.1016/j.fertnstert.2009.10.045.
4. Gilbert S.F. (2000) Developmental Biology. 6th ed. Sunderland (MA): Sinauer Associates. Osteogenesis: The Development of Bones. http://www.ncbi.nlm.nih.gov/books/NBK10056/.
5. Blumer M. (2021) Bone tissue and histological and molecular events during development of the long bones. Annals of anatomy=Anatomischer Anzeiger: official organ of the Anatomische Gesellschaft, 235: 151704. doi.org/10.1016/j.aanat.2021.151704.
6. Caplan A.I. (2005) Review: mesenchymal stem cells: cell-based reconstructive therapy in orthopedics. Tissue engineering, 11(7–8): 1198–1211. doi.org/10.1089/ten.2005.11.1198.
7. Dzhyvak V.H., Klishch I.M., Dovhalyuk A.I. et al. (2021) Changes in lipid peroxidation in experimental traumatic muscle injury and their correction with mesenchymal stem cells. Pharmacologyonline, 3: 674–679.
8. Dzhyvak V.H., Klishch I.M. (2020) Efficacy of platelet-rich blood plasma in induction of muscle tissue healing in an experimental study. Hospital Surg., 3: 36–43. doi.org/10.11603/2414-4533.2020.3.11461.
9. Everts P., Onishi K., Jayaram P. et al. (2020) Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020. Int. J. Mol. Sci., 21(20): 7794. doi.org/10.3390/ijms21207794.
10. Costa-Almeida R., Calejo I., Gomes M.E. (2019) Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies. Int. J. Mol. Sci., 20(12): 3002. doi.org/10.3390/ijms20123002.
11. Burke A.B., Collins M.T., Boyce A.M. (2017) Fibrous dysplasia of bone: craniofacial and dental implications. Oral Dis., 23(6): 697–708. doi.org/10.1111/odi.12563.
12. Bhattacharya S., Mishra R.K. (2015) Fibrous dysplasia and cherubism. Indian journal of plastic surgery: official publication of the Association of Plastic Surgeons of India, 48(3): 236–248. doi.org/10.4103/0970-0358.173101.
13. Breeland G., Sinkler M.A., Menezes R.G. (2022) Embryology, Bone Ossification. [Updated 2022 May 8]. http://www.ncbi.nlm.nih.gov/books/NBK539718/.
14. Basturk O., Askan G. (2016) Benign Tumors and Tumorlike Lesions of the Pancreas. Surg. Pathol. Clin., 9(4): 619–641. doi.org/10.1016/j.path.2016.05.007.
15. Connolly J.L., Schnitt S.J., Wang H.H. et al. (2003) Tumor Structure and Tumor Stroma Generation. In: Kufe D.W., Pollock R.E., Weichselbaum R.R. et al. (Eds.). Holland-Frei Cancer Medicine. 6th ed. Hamilton (ON): BC Decker. http://www.ncbi.nlm.nih.gov/books/NBK13447/.
16. Bowers L.M., Cohen D.M., Bhattacharyya I. et al. (2013) The non-ossifying fibroma: a case report and review of the literature. Head Neck Pathol., 7(2): 203–210. doi.org/10.1007/s12105-012-0399-7.
17. Biazzo A., Errani C., Gambarotti M. et al. (2013) Spindle cell sarcoma of bone arising from a non-ossifying fibroma: A case report. J. Clin. Orthopaed. Trauma, 4(2): 80–84. doi.org/10.1016/j.jcot.2013.04.002.
18. Evola F.R., Costarella L., Pavone V. et al. (2017) Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma. Front. Pharmacol., 8: 150. doi.org/10.3389/fphar.2017.00150.
19. Redondo A., Bagué S., Bernabeu D. et al. (2017) Malignant bone tumors (other than Ewing’s): clinical practice guidelines for diagnosis, treatment and follow-up by Spanish Group for Research on Sarcomas (GEIS). Cancer Chemother. Pharmacol., 80(6): 1113–1131. doi.org/10.1007/s00280-017-3436-0.
20. Hatano H., Morita T., Ariizumi T. et al. (2014) Malignant transformation of fibrous dysplasia: A case report. Oncol. Lett., 8(1): 384–386. doi.org/10.3892/ol.2014.2082.
21. Shi R., Li X., Zhang J. et al. (2022) Clinicopathological and genetic study of a rare occurrence: Malignant transformation of fibrous dysplasia of the jaws. Mol. Gen. Genom. Med., 10(1): e1861. doi.org/10.1002/mgg3.1861.
22. Turan S., Bastepe M. (2015) GNAS Spectrum of Disorders. Curr. Osteopor. Rep., 13(3): 146–158. doi.org/10.1007/s11914-015-0268-x.
23. Bridge J.A., Rosental H., Songer W.G., Neff J.R. (1989) Desmoplastic fibroma orising in fibrous dysplasia. Chromosomal analisis and review of the literature. Сlin. Orthop. Relat. Res., 247: 272–278.
24. Stanton R.P., Ippolito E., Springfield D. et al. (2012) The surgical management of fibrous dysplasia of bone. Orphanet. J. Rare Dis., 7(Suppl. 1): S1. doi.org/10.1186/1750-1172-7-S1-S1.
25. De Salvo S., Pavone V., Coco S. et al. (2022) Benign Bone Tumors: An Overview of What We Know Today. J. Clin. Med., 11(3): 699. doi.org/10.3390/jcm11030699.
26. Błaż M., Palczewski P., Swiątkowski J., Gołębiowski M. (2011) Cortical fibrous defects and non-ossifying fibromas in children and young adults: The analysis of radiological features in 28 cases and a review of literature. Polish J. Radiol., 76(4): 32–39.
27. Franchi A. (2012) Epidemiology and classification of bone tumors. Clinical cases in mineral and bone metabolism: the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases, 9(2): 92–95.
28. Ahlawat S., Fayad L.M. (2020) Revisiting the WHO classification system of bone tumours: emphasis on advanced magnetic resonance imaging sequences. Part 2. Polish J. Radiol., 85: e409–e419. doi.org/10.5114/pjr.2020.98686.
29. Herget G.W., Mauer D., Krauß T. et al. (2016) Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up. BMC Musculoskel. Dis., 17: 147. doi.org/10.1186/s12891-016-1004-0.
30. Rutkowski M., Niewinska K. (2021) The Epidemiology of Benign Proliferative Processes of the Skeletal System in Children. Int. J. Environment. Res. Public Health, 18(17): 9338. doi.org/10.3390/ijerph18179338.
31. Dmytrovych P.M., Volodymyrovych H.P., Orestovych K.I., Georgiyovych D.V. (2022) Pediatric high-energy and other traumatic injury: Cases and reviews. Int. J. Health Sci., 6(S1): 11513–11524. doi.org/10.53730/ijhs.v6nS1.7790.
32. Özkan E.A., Göret C.C., Özdemir Z.T. et al. (2015) Pattern of primary tumors and tumor-like lesions of bone in children: retrospective survey of biopsy results. Int. J. Clin. Exp. Pathol., 8(9): 11543–11548.