Mitochondrial dysfunction in the general continuum of non-communicable diseases from the position of systemic medicine. Part I. Literature review and results of theoretical research

February 10, 2022

The conceptual issues of the involvement of the mechanisms of mitochondrial dysfunction in the general continuum of non-communicable diseases are considered in the article.

Aim: to improve the knowledge of the etiopathogenesis of non-communicable diseases by conceptualizing the issues of systemic involvement of the mechanisms of mitochondrial dysfunction in their general continuum.

The object of the study: to identify, summarize the issues of systemic involvement of the mechanisms of mitochondrial dysfunction in non-communicable diseases, followed by a conceptual restoration in the cardiovascular and general continuum of non-communicable diseases.

Research methods: general scientific, theoretical, logical methods and normative rules.

Results. Part I presents generalized issues of the role of mitochondrial dysfunction in the pathogenesis of non-communicable diseases, identification of mechanisms and ways of primary prevention. Mitochondrial dysfunction is conceptualized as a universal pathogenetic mechanism.

Conclusions. Mitochondrial dysfunction determines the etiopathogenetic basis for the transition of the human body from a state of functional health to pathology with the gradual onset and progression of non-communicable diseases. Emphasis in the introduction of a healthy lifestyle among all segments of the population in order to prevent non-communicable diseases should be placed on: 1) preventing excess intake of food substrates (overeating); 2) avoidance of frequent, constant eating; 3) adequate nutriceptive provision of the diet; 4) prevention of hypodynamia; 5) the need to use ecological, natural food products with sufficient fiber content, normal shelf life; 6) absence of bad habits; 7) expediency of life in an ecologically clean environment.


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