Modern approaches to jaw bone regeneration: the role of bone-plastic materials and platelet-rich plasma

Objective: to systematize current scientific data on the use of bone graft materials combined with platelet-rich fibrin (PRF) for optimizing jawbone regeneration, emphasizing the potential of domestically produced materials (Bauers, ABGraft) in Ukrainian dental practice. Materials and methods. A review of scientific publications from 2015 to 2024 was conducted, sourced from PubMed, Scopus, Web of Science, and Ukrainian professional journals. Comparative analysis, synthesis of experimental and clinical data, and generalization of randomized clinical trials (RCTs) and meta-analyses were employed. Results. Bone graft materials are classified into biological (xenogeneic, e.g., Bauers, Straumann BoneCeramic) and synthetic (e.g., ABGraft, Maxresorb), providing osteoconduction and bioresorption. PRF, enriched with growth factors (PDGF, TGF-β, VEGF), promotes osteoblast proliferation, angiogenesis, and reduces healing time by 30–40%. The combined use of PRF with bone grafts increases new bone formation by 30–50% compared to monotherapy, notably in sinus lifting (bone height 10.5±1.2 mm vs. 8.7±1.5 mm; p<0.05) and periodontal defect treatment (probing depth reduction by 4.2±0.8 mm). Ukrainian materials Bauers and ABGraft are economically accessible (3–4 times cheaper than imported analogs) and comply with ISO 13485 standards but require additional RCTs for clinical validation. The relevance of regenerative technologies in Ukraine is heightened by the high incidence of war-related jaw injuries (415 cases in 2022–2024). Conclusions. The combination of PRF with bone graft materials yields a synergistic effect, enhancing jawbone regeneration. Domestic materials Bauers and ABGraft are promising for import substitution, critical for Ukraine amid post-war reconstruction. Further studies are needed to standardize PRF centrifugation protocols, evaluate long- term outcomes (beyond 12 months), and expand clinical trials for domestic materials.

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