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Кірени — прямі інгібітори реніну — новий клас лікарських засобів. Потенційні можливості клінічного застосування
Резюме. В огляді обговорюються питання щодо клінічного застосування прямих інгібіторів реніну. Розглядаються фармакокінетичні та фармакодинамічні характеристики аліскірену, який належить до цього класу лікарських засобів. Наводяться результати основних експериментальних та клінічних досліджень щодо застосування аліскірену.
Ключові слова:артеріальна гіпертензія, аліскірен, фармакокінетика, фармакодинаміка, лікування, органопротекція.
The kirens — direct renin inhibitors — novel drug class. The potential possibility for clinical implementation
Summary. Some questions about clinical implementation of direct renin inhibitors are considered. Pharmacokinetics and pharmacodynamics capacities of the direct renin inhibitor aliskiren are elucidated. Results of numerous animal and clinical studies of aliskiren application are provided.
Key words: arterial hypertension, aliskiren, pharmacokinetics, pharmacodynamics, treatment, organs protection.