Liver «under control»: effective use of diagnostic capabilities in clinical practice | Український Медичний Часопис

Сhronic liver disease (CLD) is one of the major problems of the health care system in the world. In the early stages of the disease, it is not characterized by pronounced clinical symptoms, which leads to delays in seeking medical care. Therefore, it is important to identify groups at increased risk of developing CLD and refer such patients to additional examinations with the aim of early diagnosis. However liver tests in patients with CLD may be within the normal range, which causes new challenges in diagnosis. The violation in the metabolic function of the liver was already noted at the stage of steatosis, leading to a lowering of ammonium excretion and the development of hyperammonemia in the early stages of CLD and the progression of the disease. Early detection of hyperammonemia can prevent the progression of CLD and become a new therapeutic target. Original L-ornithine-L-aspartate detoxifies ammonium and reduces the severity of hyperammonemia, which is characterized by the decrease in contractility and deactivation of the liver stellate cells, the increase in endothelial NO-synthase activity, oxide nitrogen production and suppressing the development of liver fibrosis.

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