Modern view on pathogenetic mechanisms of long-term consequences forming following mild traumatic brain injury

The article was devoted to the study of the complex pathogenetic mechanisms of metabolic changes and bioenergetic disturbances in long-term consequences following mild traumatic brain injury. It was presented the modern view and general data according to etiopathogenesis, pathomorphology and the peculiarities of the neurochemistry of any metabolic disturbances, in particular, clinical and experimental data about the functional state of free radical peroxidation of lipids, glutamate and antioxidative systems in this category of the patients, presented the modern principles of early diagnostics of this pathology. The mechanisms of development of uncontrolled intensification of lipid peroxidation, which occurs in conditions of imbalance between peroxidation processes and the activity of the antioxidant system, are considered. The available studies also demonstrate the high importance of oxidant-antioxidant relationships in the formation of energy deficiency and damage to neuronal membranes in the long term after neurotrauma.

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