Purpose: to evaluate the effect of the Vertebra complex in patients with back pain (a complication of osteochondrosis). Object and research methods. A randomized controlled clinical trial with a double-blind placebo-controlled period lasting 3 months was conducted. The study involved 30 (16 men and 14 women) patients aged 18–65 (38.4±3.8) years old with complications of osteochondrosis who underwent a rehabilitation course at the Center for Kinesitherapy and Rehabilitation «Vyshcha Liga». The participants were randomized into two groups: in the 1st group, the Vertebra complex was prescribed for 1 sachet 2 times a day for 3 months with standard therapy (non-steroidal anti-inflammatory drugs, muscle relaxants, group B vitamins); the 2nd group received only standard therapy. All patients worked out for 3 months in the hall of rehabilitation simulators, with dosed physical activity. The results. All study participants noted a decrease in the severity of pain within 3 months, but patients who used the Vertebra complex noted a more stable pain relief effect and in a shorter period of time. Conclusion. The inclusion of the Vertebra complex in the treatment regimen in patients with complications of osteochondrosis has a clinical advantage compared to patients who received only standard therapy.