Objective: To investigate the local inflammatory response characteristics in patients with chronic wounds. Materials and methods. The study focused on neutrophilic granulocytes, monocytes, reactive oxygen species (ROS), the antioxidant system, and the levels of pro- and anti-inflammatory cytokines in the capillary blood of the wound area. The study involved 20 patients with chronic wounds undergoing treatment at the Burn Unit of Kyiv City Clinical Hospital № 2. Methods included a clinical prospective analysis, the nitroblue tetrazolium test, measurement of myeloperoxidase activity, ROS and superoxide dismutase levels, as well as enzyme-linked immunosorbent assay to assess the cytokine profile. Results. Dysfunction in the functional activity of neutrophilic granulocytes in the wound area was identified, including decreased myeloperoxidase activity and an increased number of cells with apoptotic changes. Elevated ROS levels and reduced antioxidant activity of superoxide dismutase were found to contribute to oxidative stress. A significant imbalance between pro-inflammatory cytokines (interleukin-1, tumor necrosis factor-α) and the anti-inflammatory cytokine (interleukin-6) was observed, exacerbating chronic inflammation and hindering wound healing. Conclusion. Patients with chronic wounds exhibit significant dysfunction of innate immune cells, oxidative stress, and cytokine imbalance, which impede reparative processes and represent critical therapeutic targets.