Objective: to provide proposals of the most important research spheres in human exposome in Ukraine and the resources needed for implementation. Materials and methods. The article contains a literary review of exposome studies since 2012 and comparative analysis of the burden of diseases and their dynamics in Ukraine since 1990 till 2017. Results. In February 2020 the European Network on Human Exposure brought together 126 research centers from 24 European countries and identified 9 global areas of activity. In Ukraine, the most common causes of death due to non-communicable diseases among people aged 15–49 are coronary heart disease, stroke, cirrhosis, and chronic liver disease, alcohol abuse, and drug use. Conclusion. The participation of Ukrainian specialists and institutions in exposome studies will make a significant contribution to reducing non-communicable diseases and improving the health of Ukrainians, strengthening the human and scientific potential of higher education and research institutions, providing a strong international partnership for further development of research & practical cooperation with European countries.