The aim is to conduct a comprehensive assessment of immunogenetic and biochemical parameters in patients with chronic viral hepatitis B (CVHB) living in the Odesa region. Materials and methods. A total of 82 patients with CVHB were examined. The traditional biochemical and immunological parameters, the content of cytokines IL-4, IL-10, TNF-α and the gene polymorphism of cytokines interleukin (IL)-4, IL-10, tumor necrosis factor (TNF)-α were determined. The patients were divided into groups in accordance with the identified polymorphisms of cytokine genes for assess the relationship of non-parametric and parametric indicators (changes in the immunological status, biochemical parameters and cytokine profile) Results. With the use of the Spearman’s rank correlation coefficient, certain relationships have been established. In patients with homozygous CC IL-4 polymorphism, more pronounced changes in the cytokine profile, immunological status and a higher level of alanine aminotransferase and aspartate aminotransferase activity were noted. Conclusion. The revealed relationship between the alanine aminotransferase and aspartate aminotransferase levels, the immunological status and cytokine profile indicators with certain TNF-α and IL-4 genotypes suggests a genetic predisposition of certain patients with CVHB to a more severe course. The information obtained can be applied as one of the additional criteria for the activity of inflammatory changes in the liver tissue.