Objective: to assess the clinical effectiveness of perindopril in patients with isolated arterial hypertension (AH) by analyzing the dynamics of blood pressure, biochemical parameters, markers of cardiovascular risk and structural and functional state of the heart. Object and methods of the study. 49 patients with isolated AH were examined, who were prescribed perindopril at a dose of 2–8 mg/day for 12 months. The dynamics of hemodynamic parameters, lipid metabolism indicators, kidney function (creatinine, cystatin C, glomerular filtration rate, NGAL), cardiac stress markers (NT-proBNP, cardiotrophin-1), as well as echocardiography results were assessed. Statistical analysis was performed using paired t-test and Wilcoxon criterion. Results. A significant decrease in systolic and diastolic blood pressure, improvement in lipid profile, decrease in NT-proBNP, cardiotrophin-1, cystatin C, NGAL levels and improvement in renal function were detected. Echocardiography showed regression of the atrial, right ventricular and left ventricular end-systolic dimensions. Other parameters remained stable. Conclusion. Perindopril effectively reduces blood pressure, improves the cardiometabolic profile and structural parameters of the heart, which confirms its feasibility in the treatment of isolated AH.