Objective: Increasing the effectiveness of septoplasty by prognostic substantiation of the optimal volume of surgical intervention on the structures of the anterior and upper parts of the nose on the basis of preoperative videoendorhinoscopy examination with computer bioimaging of images of the nasal cavity and planimetry of its lumen. Materials and methods. 108 patients who underwent surgery for nasal septum deformation and nasal breathing disorders were examined. The first group comprised 66 patients who were retrospectively assessed after septoplasty performed using the traditional Cottle surgery, with some also undergoing correction of the inferior nasal valve (INV) as determined by the surgeon visually during the procedure. The second group included 42 patients who underwent septoplasty using the traditional Cottle surgery, with the decision to correct the INV based on predictions derived from differences between real and theoretically justified boundaries, as determined from photo images of video endorinoscopy. In all patients, quality of life was assessed using the Sino-Nasal Outcome Test-22 (SNOT-22) questionnaire, and computerized anterior active rhinomanometry and olfactometry tests were conducted using «Sniffin’Sticks». Results. According to the «Sniffin’ Sticks» tests, the overall olfactory acuity index was 9.48±0.18 points in patients of Group I and 10.45±0.18 points in patients of Group 2 (p<0.05). It was also found that the quality of life outcomes after septoplasty were significantly better in patients of Group 2 compared to those in Group 1. Conclusion. The effectiveness of septoplasty, with prediction of the extent of surgical intervention on the structures of the anterior and upper parts of the nose based on preoperative videoendorhinoscopy examination and computer bioimaging processing of INV images, is higher compared to the traditional approach by 20.8% according to the SNOT-22 indicator (from 69.7% to 90.5%; p<0.05).