Purpose: to study the state of the organization of infectious safety and to offer multimodal strategies for its improvement in dental healthcare facilities. The object of research: infectious safety systems in tertiary care facilities of dental profile. The subject of research: the organizational structure, functions, tools, measures for infectious safety in the studied institutions. Research methods: system approach; comparative, logical and structural analysis; descriptive modeling; graphic. Results. It is established that infectious safety systems operate in accordance with regulatory requirements. However, infection prevention and control programs do not include measures to vaccinate health workers against parenteral hepatitis and influenza and to strengthen the culture of infectious safety, there are no clear criteria for monitoring and evaluating preventive measures. There are no tools for self-control on infectious safety issues, internal audit is used to a limited extent; clear interaction between all stakeholders is not established; infrastructure components (engineering networks, communications) are separated from the infectious safety system. Traditional methods of staff training are used in the workplace. Multimodal strategies based on world evidence-based practices on infectious safety have been proposed to be used to improve the organization of infectious safety activities. It is recommended to introduce checklists as carriers of criteria for monitoring, evaluation and self-control tools, use of internal thematic audit, establishment of communications between stakeholders, introduction of interactive forms of employee training in the workplace and strengthening the culture of infectious safety. Conclusions. The use of a set of multimodal strategies based on world evidence-based practices will ensure the improvement of infectious safety measures in dental healthcare facilities.