Aim: to assess the prognostic value of comorbid conditions in patients with obesity for predicting clinical outcomes following sleeve gastrectomy in the long-term postoperative period. Materials and methods. Clinical outcomes were analyzed in 93 patients with obesity (69 women (74.19%) and 24 men (25.81%)) who underwent sleeve gastrectomy. The mean age was 42.20±11.09 years. Clinical outcomes were evaluated using the SF-BARI Score QoL scale. Comorbid conditions were assessed using the Charlson Comorbidity Index. Results. Predictive factors for satisfactory outcomes after sleeve gastrectomy included the presence of heart failure (OR 10.43, 95% CI 1.70–64.06; p=0.008), peripheral vascular disease (OR 9.88, 95% CI 1.66–58.64; p=0.02), chronic non-specific pulmonary disease (OR 14.00, 95% CI 1.75–111.93; p=0.02), and a Charlson Comorbidity Index ≥6 (OR 28.00, 95% CI 3.80–206.53; p=0.002). A higher probability of favorable clinical outcomes was observed in patients with liver cirrhosis without portal hypertension (OR 11.83, 95% CI 1.13–124.44; p=0.02) and in those with a Charlson Index 3–5 (OR 2.94, 95% CI 1.05–8.22; p=0.04). Significantly poorer outcomes were associated with a history of stroke (τ=–0.20, p=0.005), dementia (τ=–0.15; p=0.03), diabetes mellitus with peripheral complications (τ=–0.18; p=0.01). A Charlson Index 0–2 was significantly associated with very good surgical outcomes (OR 3.13, 95% CI 1.20–8.13; p=0.01). Conclusion. This study confirms the high prognostic value of comorbid conditions in predicting clinical outcomes of sleeve gastrectomy in patients with obesity.