Aim: to study the state of the antioxidant system of patients with diabetic foot syndrome and to improve the results of their complex treatment. Object and methods of research. The study included 134 patients with diabetic foot syndrome. Patients were divided by sex and age: men — 85 (63.4%), women — 49 (36.6%), the average age was (64.3±7.3 years). To study the antioxidant system, we determined for 1, 7, 14 days in the wound and serum the content of metabolites of reactive oxygen species of TBA-active products in blood plasma, the activity of the antioxidant system superoxide dismutase. Peripheral blood monocyte functional activity was assessed in the nitrosine tetrazolium reduction test in two modifications: spontaneous and lipopolysaccharide-induced. Results. When determining the activity of superoxide dismutase in peripheral blood in patients who received glutathione in complex treatment, we found a decrease in its activity relative to reference values 1.56 times (p<0.001). Conclusions. Oxidative stress leads to a cascade of pathomorphological changes in the body, which dictates the need to use antioxidant therapy in the treatment of diabetic foot syndrome.