The aim was to evaluate the impact of toxigenic (cagA +, vacA +) strains of Helicobacter pylori (H. pylori) on the quality of life in patients with peptic ulcer of the stomach and duodenum in combination with hypertension and type 2 diabetes mellitus. Research methods. Fibrogastroduodenoscopy using the device «GIF-Q40» with targeted biopsy using the test system «HELIK^®» with indicator tubes were used to verify the diagnosis. The cagA and vacA genes of H. pylori in biopsies were determined using «Helicopol» reagent kits. Eradication efficiency was monitored 4 weeks after completion of proton-pump inhibitors and antibacterial treatment using a urease breath test and immunochromatographic test systems to detect H. pylori antigen in faeces «CITO TEST^® H. Рylori Ag». Results. It is investigated that viability, mental health and physical role activity are most increased in groups of patients with peptic ulcer and duodenum ulcer in combination with arterial hypertension and type 2 diabetes mellitus. Conclusion. The combination therapy improved the condition of the patients. The addition of a probiotic to anti-Helicobacter pylori therapy improved their quality of life.