Neuroinflammation as a Pathogenetic Target of Cognitive Recovery after Mine-Explosive Trauma | Ukrainian Medical Journal

Mine-explosive trauma causes not only primary mechanical brain damage, but also a long-term secondary neuroinflammatory cascade, which often determines the persistence of cognitive deficits, even in the absence of structural changes during neuroimaging. The article reviews the pathogenetic role of neuroinflammation, its relationship with tau pathology, post-traumatic stress disorder, and mental exhaustion in military personnel, as well as practical guidelines for the doctor regarding the time window of therapeutic intervention. The preclinical and clinical evidence base of the standardized Ginkgo biloba extract EGb 761^® (Memoplant^® Forte) as a pathogenetically directed component of supporting cognitive recovery after contusion was separately analyzed.

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