Age-related features of cerebral hemodynamics and brain metabolism during the recovery period following a stroke

Stroke is a highly disabling disease, which determines its medical and social relevance. Arterial hypertension and age are among the important risk factors for both the development and course of stroke. Arterial hypertension is a major risk factor for premature aging, stroke, and mortality. Elevated blood pressure is directly associated with cardiovascular complications such as myocardial infarction, sudden cardiac death, stroke, and renal failure. The World Health Organization and the International Society of Hypertension (WHO–ISH) emphasize the importance of active treatment for patients with hypertension, especially when it is combined with diabetes mellitus, diabetic nephropathy, and other concomitant target organ damage. To date, the presence and age-related characteristics of the pathogenetic mechanisms underlying the clinical onset and course of stroke have been established, which necessitates the development of effective methods for prevention, treatment, and rehabilitation, taking into account the age-related characteristics of metabolic, hemodynamic, and morphometric reorganization of the brain in patients who have suffered a stroke.