From Stress to Cephalalgia (Headache): Psychosomatic Mechanisms, Neurobiology and Strategy of Physiological Correction

The article reviews psychosomatic and neurobiological mechanisms of stress-induced cephalalgia formation, in particular the role of chronic stress, anxiety, sleep disorders, central sensitization and neurotransmitter imbalance. The feasibility of complex physiological correction aimed at reducing neuronal hyperexcitability, improving emotional state and normalizing sleep is substantiated. The results of an open prospective study of the effectiveness of the drug Lagison in 56 patients with psychosomatic forms of headache are presented. The main group received Lagison as part of complex therapy for one month, the control group received placebo. The assessment was carried out using the VRS, GAD-7, HADS, PSQI and CQLS scales. It was found that the use of Lagison was associated with a decrease in headache intensity, anxiety level, improved sleep quality and quality of life compared to the control group. The obtained data indicate the prospects of using the drug in the complex correction of psychosomatic cephalalgia and require further confirmation in randomized controlled trials.

References

1. Ashina M. (2020) Migraine. N. Engl. J. Med., 383(19): 1866–1876. doi: 10.1056/NEJMra1915327.
2. Sic A., Bogicevic M., Brezic N. et al. (2025) Chronic Stress and Headaches: The Role of the HPA Axis and Autonomic Nervous System. Biomedicines, 13(2): 463. doi: 10.3390/biomedicines13020463.
3. Arslan M., Hatık S.H. (2026) Investigating the relationships between headache characteristics and physical activity, autonomic function, psychological status, and quality of life in individuals with tension-type headache. BMC Neurol., 26(1): 42. doi: 10.1186/s12883-025-04616-4.
4. Romero-Godoy R., Romero-Godoy S.R., Romero-Acebal M., Gutiérrez-Bedmar M. (2022) Psychiatric Comorbidity and Emotional Dysregulation in Chronic Tension-Type Headache: A Case-Control Study. J. Clin. Med., 11(17): 5090. doi: 10.3390/jcm11175090.
5. Suzuki K., Suzuki S., Shiina T. et al. (2022) Central Sensitization in Migraine: A Narrative Review. J. Pain Res., 15: 2673–2682. doi: 10.2147/JPR.S329280.
6. Wang L., Wang Y., Zhou S. et al. (2016) Imbalance between Glutamate and GABA in Fmr1 Knockout Astrocytes Influences Neuronal Development. Genes (Basel), 7(8): 45. doi: 10.3390/genes7080045.
7. Frederiksen S.D., Bekker-Nielsen Dunbar M., Snoer A.H. et al. (2020) Serotonin and Neuropeptides in Blood From Episodic and Chronic Migraine and Cluster Headache Patients in Case-Control and Case-Crossover Settings: A Systematic Review and Meta-Analysis. Headache, 60(6): 1132–1164. doi: 10.1111/head.13802.
8. Whibley D., AlKandari N., Kristensen K. et al. (2019) Sleep and Pain: A Systematic Review of Studies of Mediation. Clin. J. Pain, 35(6): 544–558. doi: 10.1097/AJP.0000000000000697.
9. Benoit S., Chaumontet C., Violle N. et al. (2022) The Anxiolytic-like Properties of a Tryptic Hydrolysate of Bovine αs1 Casein Containing α-Casozepine Rely on GABAA Receptor Benzodiazepine Binding Sites but Not the Vagus Nerve. Nutrients, 14(11): 2212. doi: 10.3390/nu14112212.
10. Lalonde R. (2024) Anxiolytic-like effects of milk proteins. Pharmacol. Biochem. Behav., 240: 173789. doi: 10.1016/j.pbb.2024.173789.
11. Chiu H.Y., Yeh T.H., Huang Y.C., Chen P.Y. (2016) Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled Trials. Pain Physician, 19(1): E97–E112.
12. Parra M., Stahl S., Hellmann H. (2018) Vitamin B6 and Its Role in Cell Metabolism and Physiology. Cells, 7(7): 84. doi: 10.3390/cells7070084.
13. Chaban O., Khaustova O., Bezsheyko V. (2016) New Quality of Life Scale in Ukraine: Reliability and Validity. Indian J. Social Psychiatr., 32(4): 473.
14. Chaban O., Khaustova O., Bezsheiko V. (2016) Reliability and validity of Chaban Quality of Life Scale. 29th ECNP Congress, 18–22 Sep., Vienna. Poster P2h301.
15. Діагностика непсихотичних психічних розладів у пацієнтів з хронічними неінфекційними захворюваннями на етапі первинної медичної допомоги. Методичні рекомендації. МОЗ України, Київ, 2014.
16. Тривога в загальносоматичній практиці: досвід використання препарату Нікомекс. Практикуючий лікар, 2017 (1): 56–60.
17. Чабан О.С. (ред.) (2017) Практикум з підвищення стресостійкості та розширення адаптаційних можливостей організму. Доктор-Медіа-Груп, Київ, 150 с.