Clinical and diagnostic parallels between arachnoid cysts and concomitant diseases in general medical practice

April 24, 2026
26
УДК:  616.831.9/.832.93-008.8-007-06-079.4-036-08
Resume

The article considers the current issues of diagnostic search in the comorbid course of arachnoid cysts, arterial hypertension and cephalgic syndrome in general medical practice. The problem of hyperdiagnosis is highlighted, when the symptoms of hypertension are mistakenly interpreted as manifestations of fluid dynamic disorders. Attention is focused on the importance of a differential approach: determining the genesis of headache and assessing the clinical significance of the cyst. An algorithm of doctor’s tactics is proposed, which allows avoiding unjustified hospitalizations and ensuring timely control of blood pressure while maintaining dynamic observation of neuroimaging changes. The role of modern imaging methods (MRI, CT) in monitoring the dynamics of cyst development and preventing possible complications is determined. Methods. A literature review was conducted in the electronic databases PubMed/MEDLINE, Embase for the period 2002–2026 using the following keywords: «arachnoid cyst», «arterial hypertension», «headache», «comorbidity». A relevant clinical case is described, which emphasizes the importance of distinguishing between fluid dynamic disorders and hypertensive disorders in this genesis. Results. Intracranial arachnoid cysts are a common incidental finding during brain neuro­imaging. Most of them are associated with congenital pathology, their localization and size do not correlate with the severity of arterial hypertension or the intensity of headache. Detection of arachnoid cysts on MRI often becomes a source of additional anxiety, therefore it is important to distinguish between their symptomatic nature or the absence of a direct causal relationship between the cyst and the patient’s complaints. This emphasizes the role of the general practitioner in the depathologizing of incidental findings. Conclusions. It is critically important to distinguish between fluid dynamic disorders caused by an arachnoid cyst and symptoms of hypertension. An undifferentiated approach to the genesis of headache leads to misinterpretation of the arachnoid cyst as the main pathological factor, which entails unjustified polypharmacy and untimely correction of blood pressure. Identification of specific «red flags» (for example, progressive intracranial hypertension) is the only reason for changing tactics from conservative to neurosurgical.

References

  • 1. Ahmed A.K., Cohen A.R. (2023) Intracranial arachnoid cysts. Childs Nerv. Syst., 39(10): 2771–2778. doi: 10.1007/s00381-023-06066-0.
  • 2. Bhattarai H.B., Sapkota S., Mandal P. et al. (2023) Arachnoid cyst presenting as a neurosurgical emergency: a case report. Ann. Med. Surg. (Lond.), 85(12): 6164–6167. doi: 10.1097/MS9.0000000000001373.
  • 3. Al-Holou W.N., Terman S., Kilburg C. et al. (2013) Prevalence and natural history of arachnoid cysts in adults. J. Neurosurg., 118(2): 222–231. doi: 10.3171/2012.10.JNS12548.
  • 4. Hall S., Smedley A., Sparrow O. et al. (2019) Natural History of Intracranial Arachnoid Cysts. World Neurosurg., 126: e1315–e1320. doi: 10.1016/j.wneu.2019.03.087.
  • 5. Starkman S.P., Brown T.C., Linell E.A. (1958) Cerebral arachnoid cysts. J. Neuropathol. Exp. Neurol., 17(3): 484–500. doi: 10.1097/00005072-195807000-00009.
  • 6. Rabiei K., Tisell M., Wikkelsø C., Johansson B.R. (2014) Diverse arachnoid cyst morphology indicates different pathophysiological origins. Fluids Barriers CNS, 11(1): 5. doi: 10.1186/2045-8118-11-5.
  • 7. White M.L., Das J.M. (2024) Arachnoid Cysts. In: StatPearls. Treasure Island (FL): StatPearls Publ.
  • 8. Harris P.C., Torres V.E. (2022) Polycystic Kidney Disease, Autosomal Dominant. In: Adam M.P., Bick S., Mirzaa G.M. et al. (Eds.) GeneReviews®. Seattle (WA): University of Washington, Seattle; 1993–2026.
  • 9. Gaillard F., Knipe H., Yasin W. та ін. Класифікація павутинної кісти середньої черепної ямки за методом Галассі. doi.org/10.53347/rID-4346.
  • 10. de Longpre J. (2017) Large Arachnoid Cyst. N. Engl. J. Med., 376(23): 2265. doi: 10.1056/NEJMicm1610483.
  • 11. Bison H.S., Janetos T.M., Russell E.J., Volpe N.J. (2024) Cranial Nerve Palsies in the Setting of Arachnoid Cysts: A Case Series and Literature Review. J. Neuroophthalmol., 44(2): 242–246. doi: 10.1097/WNO.0000000000001983.
  • 12. Bigder M.G., Helmi A., Kaufmann A.M. (2017) Trigeminal neuropathy associated with an enlarging arachnoid cyst in Meckel’s cave: case report, management strategy and review of the literature. Acta Neurochir. (Wien), 159(12): 2309–2312. doi: 10.1007/s00701-017-3262-5.
  • 13. Kaur K., Patel B.C. Optic Nerve Cysts. 2025 Jan 19. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2026.
  • 14. Mahboob M., Rout P., Bokhari S.R.A. (2024) Autosomal Dominant Polycystic Kidney Disease. In: StatPearls. Treasure Island (FL): StatPearls Publ.
  • 15. Ozaki K., Higuchi Y., Nakano S. et al. (2022) Arachnoid cyst alone causes hemifacial spasm: illustrative case. J. Neurosurg. Case Lessons, 3(15): CASE2275. doi: 10.3171/CASE2275.
  • 16. Pagni C.A., Canavero S., Vinci V. (1990) Left trochlear nerve palsy, unique symptom of an arachnoid cyst of the quadrigeminal plate. Case report. Acta Neurochir. (Wien), 105(3–4): 147–149. doi: 10.1007/BF01669999.
  • 17. Algin O. (2018) Evaluation of the Communication Between Arachnoid Cysts and Neighboring Cerebrospinal Fluid Spaces by T2W 3D-SPACE With Variant Flip-Angle Technique at 3 T. J. Comput. Assist. Tomogr., 42(5): 816–821. doi: 10.1097/RCT.0000000000000751.
  • 18. Jafrani R., Raskin J.S., Kaufman A., Lam S. (2019) Intracranial arachnoid cysts: Pediatric neurosurgery update. Surg. Neurol. Int., 10: 15. doi: 10.4103/sni.sni_320_18.
  • 19. Wang J.Y., Hadi H., Arshad M., Whitney E. (2025) A Comprehensive Review of Arachnoid Cysts. Cureus, 17(5): e83894. doi: 10.7759/cureus.83894.
  • 20. El Damaty A., Issa M., Paggetti F. et al. (2023) Intracranial arachnoid cysts: What is the appropriate surgical technique? A retrospective comparative study with 61 pediatric patients. World Neurosurg. X., 19: 100195. doi: 10.1016/j.wnsx.2023.100195.
  • 21. Budhram B., Akbari A., Brown P. et al. (2018) End-Stage Kidney Disease in Patients With Autosomal Dominant Polycystic Kidney Disease: A 12-Year Study Based on the Canadian Organ Replacement Registry. Can. J. Kidney Health Dis., 5: 2054358118778568. doi: 10.1177/2054358118778568.
  • 22. Bergmann C., Guay-Woodford L.M., Harris P.C. et al. (2018) Polycystic kidney disease. Nat. Rev. Dis. Primers, 4(1): 50. doi: 10.1038/s41572-018-0047-y.
  • 23. Al Sayyab M., Chapman A. (2023) Pregnancy in Autosomal Dominant Polycystic Kidney Disease. Adv. Kidney Dis. Health, 30(5): 454–460. doi: 10.1053/j.akdh.2023.10.006.
  • 24. Perrone R.D., Oberdhan D., Ouyang J. et al. (2023) OVERTURE: A Worldwide, Prospective, Observational Study of Disease Characteristics in Patients With ADPKD. Kidney Int. Rep., 8(5): 989–1001. doi: 10.1016/j.ekir.2023.02.1073.
  • 25. Kalatharan V., Grewal G., Nash D.M. et al. (2020) Stone Prevalence in Autosomal Dominant Polycystic Kidney Disease: A Systematic Review and Meta-Analysis. Can. J. Kidney Health Dis., 7: 2054358120934628. doi: 10.1177/2054358120934628.
  • 26. KC M., Leslie S.W. (2023) Uric Acid Nephrolithiasis. In: StatPearls. Treasure Island (FL): StatPearls Publ.
  • 27. Schrier R.W., Abebe K.Z., Perrone R.D. et al.; HALT-PKD Trial Investigators (2014) Blood pressure in early autosomal dominant polycystic kidney disease. N. Engl. J. Med., 371(24): 2255–2266. doi: 10.1056/NEJMoa1402685.
  • 28. Müller R.U., Benzing T. (2018) Management of autosomal-dominant polycystic kidney disease-state-of-the-art. Clin. Kidney J., 11(Suppl. 1): i2–i13. doi: 10.1093/ckj/sfy103.