The influence of the intestinal microbiome on the pathogenesis of endometriosis and strategies for dietary correction of the condition of patients

The relevance of the study is determined by the increasing prevalence of endometriosis and the need for in-depth study of its systemic pathogenetic mechanisms. The purpose of the article is to scientifically substantiate the role of the intestinal microbiome in the formation of the pathogenetic mechanisms of endometriosis and to determine the possibilities of using dietary strategies to correct the condition of patients. The study used methods of analysis, systematization, and generalization of scientific sources, comparative analysis of modern biomedical research, as well as structural and logical generalization of results to determine the relationships between the state of the intestinal microbiome, metabolic processes, and the course of endomet­riosis. The object of the study is the pathogenetic mechanisms of endometriosis associated with the functioning of the intestinal microbiome. As a result of the study, scientific data on the relationship between the state of the intestinal microbiome, hormonal regulation, and immune mechanisms were generalized. It has been established that dysbiotic changes in the intestinal microbiota can affect estrogen metabolism through the enzymatic activity of estrobom, alter hormone balance, and maintain the estrogen-dependent nature of the pathological process. It has been found that disturbances in microbial diversity are accompanied by changes in immune regulation and an increase in systemic inflammatory reactions, which contribute to the survival and implantation of ectopic endometrial cells. It has been proven that diet can modify the composition and functional activi­ty of the gut microbiota, influence the synthesis of bacterial metabolites, and affect the intensity of inflammatory processes in the body. The conclusions indicate that the gut microbiome is an important factor in the systemic regulation of hormonal, immune, and metabolic processes associated with the development of endometriosis. The feasibility of using dietary strategies as part of a comprehensive approach to patient management aimed at stabilizing the microbiota, reducing systemic inflammation, and maintaining the body’s metabolic balance is justified.