The influence of psycho-emotional factors on the development of functional disorders of the digestive system in children

November 28, 2025
324
УДК:  616.89-053.2:616.33/.34
Resume

Current scientific data on the influence of psychoemotional factors on the development of functional disorders of the digestive system in children are analysed. The psychosomatic approach is based on the interconnection between mental, biological and social factors, which together form the clinical picture of gastroenterological diseases. Particular attention is paid to the role of the brain–gut axis, through which psycho-emotional stress, anxiety and depression affect the motor, secretory and immune functions of the gastrointestinal tract. Dysbiosis, impaired barrier function of the mucous membrane and changes in serotonin regulation are key links in the pathogenesis of functional disorders. The results of foreign and domestic studies confirm that psycho-emotional states significantly correlate with the frequency and severity of symptoms of irritable bowel syndrome, functional abdominal pain, constipation, and inflammatory bowel diseases in children. A link has been found between stress, family conflicts, school problems (bullying), and traumatic events and the development or exacerbation of gastrointestinal symptoms. The role of somatisation as a mechanism that transforms emotional experiences into physical complaints, especially in children with anxious-avoidant or asthenic personality types, is considered. Psychometric instruments (SCAS, CASI, STAIC, PHQ-9, GAD-7) are described, which allow for the quantitative assessment of anxiety, depression, and somatisation levels, which is crucial for early diagnosis and risk stratification. The results of clinical observations during martial law are highlighted, confirming that chronic stress exacerbates psychoemotional and somatic symptoms in children with functional gastrointestinal disorders. It is summarised that psycho-emotional factors are not only comorbid conditions but also modifiers of disease progression due to increased visceral sensitivity, changes in microbiota and activation of the hypothalamic-pituitary-adrenal axis. The feasibility of integrating psychological interventions (cognitive-behavioural therapy, hypnotherapy, stress management methods) into comprehensive treatment has been substantiated, which will contribute to the personalisation of care and improve the quality of life of children.

References

  • 1. Deter H.C. (2016) History, concepts and aims of internationally active societies in psychosomatic and behavioural medicine. BioPsychoSocial Med., 10: 34.
  • 2. Feng L., Li Z., Gu X. et al. (2021) Psychosomatic disorders in patients with gastrointestinal diseases: single-center cross-sectional study of 1186 inpatients. Gastroenterol. Res. Pract., 2021: 6637084. doi.org/10.1155/2021/6637084.
  • 3. Fava G.A., Sonino N. (2000) Psychosomatic medicine: emerging trends and perspectives. Psychother. Psychosomat., 69(4): 184–197. doi.org/10.1159/000012393.
  • 4. Zhang Q., Ding L., Cao J. (2022) Evolution and significance of the psychosomatic model in gastroenterology. General Psychiatr., 35(5): e100856.
  • 5. Al-Beltagi M., Saeed N.K., Bediwy A.S., Elbeltagi R. (2025) Breaking the cycle: Psychological and social dimensions of pediatric functional gastrointestinal disorders. World J. Clin. Pediatr., 14(2): 103323. doi.org/ 10.5409/wjcp.v14.i2.103323.
  • 6. Mayer E.A., Nance K., Chen S. (2022) The gut-brain axis. Ann. Rev. Med., 73: 439–453.
  • 7. Kumar A., Vallabhaneni P. (2025) Anxiety disorders presenting as gastrointestinal symptoms in children — a scoping review. Clin. Experiment. Pediatr., 68(5): 344–351. doi.org/10.3345/cep.2024.01732.
  • 8. Surdea-Blaga T., Băban A., Dumitrascu D.L. (2012) Psychosocial determinants of irritable bowel syndrome. World J. Gastroenterol., 18(7): 616–626.
  • 9. Hommel K.A., McGraw K.L., Ammerman R.T. et al. (2010) Psychosocial functioning in children and adolescents with gastrointestinal complaints and disorders. J. Clin. Psychol. Med. Sett., 17(2): 159–166. doi.org/10.1007/s10880-010-9193-4.
  • 10. Foster J.A., Rinaman L., Cryan J.F. (2017) Stress & the gut-brain axis: regulation by the microbiome. Neurobiol. Stress, 7: 124–136. doi.org/10.1016/j.ynstr.2017.03.001.
  • 11. Gozali F.S., Febiana B., Putra I.G.N.S. et al. (2023) Relationship between psychological stress with functional constipation in children: a systematic review. The Pan African Med. J., 46: 8. doi.org/10.11604/pamj.2023.46.8.41130.
  • 12. Pop D., Man S.C., Farcău D. (2025) Anxiety and depression in children with irritable bowel syndrome — a narrative review. Diagnostics, 15(4): 433.
  • 13. Sun Y., Li L., Xie R. et al. (2019) Stress triggers flare of inflammatory bowel disease in children and adults. Frontiers in Pediatrics, 7: 432.
  • 14. Belei O., Basaca D.-G., Olariu L. et al. (2024) The interaction between stress and inflammatory bowel disease in pediatric and adult patients. J. Clin. Med., 13(5): 1361.
  • 15. Dufton L.M., Dunn M.J., Compas B.E. (2009) Anxiety and somatic complaints in children with recurrent abdominal pain and anxiety disorders. J. Pediatr. Psychol., 34(2): 176–186. doi.org/10.1093/jpepsy/jsn064.
  • 16. Díez-Suárez A., Hernández-González C. (2025) Somatization in childhood and adolescence: a guide to facilitate its understanding. Anales de Pediatría, 102(2): 503711.
  • 17. Rodríguez-Menchón M., Orgilés M., Espada J.P., Morales A. (2022) Validation of the brief version of the Spence Children’s Anxiety Scale for Spanish children (SCAS-C-8). J. Clin. Psychol., 78(6): 1093–1102. doi.org/10.1002/jclp.23263.
  • 18. Wright K.D., Asmundson G.J., McCreary D.R. et al. (2010) Confirmatory factor analysis of the Childhood Anxiety Sensitivity Index: a gender comparison. Cognitive Behav. Ther., 39(3): 225–235. doi.org/10.1080/16506073.2010.486840.
  • 19. Williams A.E., Czyzewski D.I., Self M.M., Shulman R.J. (2015) Are child anxiety and somatization associated with pain in pain-related functional gastrointestinal disorders? J. Health Psychol., 20(4): 369–379. doi.org/10.1177/1359105313502564.
  • 20. Слюсар Н., Волосовець О., Хаустова О., Кривопустов С. (2025) Оцінка тривожності у дітей з функціональними гастроінтестинальними розладами, що супроводжуються абдомінальним болем, в умовах воєнного стану. Здоров’я дитини, 20(5): 384–391. doi.org/10.22141/2224-0551.20.5.2025.1875.
  • 21. Сорокман Т.В., Черней Н.Я., Макарова О.В., Колєснік Д.І. (2024) Частота тривожно-депресивного синдрому в дітей, хворих на запальні захворювання кишечника. Сучасна педіатрія. Україна, 1(137): 102–104.
  • 22. Semen M., Lychkovska O. (2023) Trait anxiety and somatization levels in children with irritable bowel syndrome. Child’s Health, 18(1): 53–59.
  • 23. Kucher S.V., Mudra U.O., Hanberher I.I. et al. (2025) Investigation of increased levels of anxiety and depression impact on the quality of life in patients with irritable bowel syndrome. World Med. Biol., 2(92): 89–94.
  • 24. Govindasamy V., Mashayekhi Y., Khan M.N. et al. (2025) Association between gastrointestinal symptoms and anxiety levels in patients with functional dyspepsia. Cureus, 17(5): e84810. doi.org/10.7759/cureus.84810.
  • 25. Pranckeviciene A., Saudargiene A., Gecaite-Stonciene J. et al. (2022) Validation of the Patient Health Questionnaire-9 and the Generalized Anxiety Disorder-7 in Lithuanian student sample. PLoS One, 17(1): e0263027.
  • 26. Sun J., Liang K., Chi X., Chen S. (2021) Psychometric properties of the Generalized Anxiety Disorder Scale-7 item (GAD-7) in a large sample of Chinese adolescents. Healthcare, 9(12): 1709. doi.org/10.3390/healthcare9121709.
  • 27. Fortini S., Costanzo E., Rellini E. et al. (2024) Use of the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) questionnaires for clinical decision-making and psychological referral in ophthalmic care: a multicentre observational study. BMJ Open, 14(1): e075141.