Key lifestyle indicators in women with post-traumatic stress disorder and their role in the development of recurrent pregnancy loss

Purpose: to investigate lifestyle characteristics in women with post-traumatic stress disorder (PTSD) and their role in the development of recurrent pregnancy loss (RPL).

The object of research: lifestyle of reproductive-age women (20–40 years) with PTSD. The subject of research: impact of adverse lifestyle factors (smoking, alcohol and caffeine consumption, sleep disorders, insufficient physical activity) on the frequency of RPL in women with PTSD. Methods: clinical interviewing, analysis of medical records, standardized questionnaires (Health-Promoting Lifestyle Profile II, PCL-C, CAPS-5), gynecological and ultrasound examinations, laboratory and statistical methods.

Results. Women with PTSD showed a high prevalence of sleep disorders (up to 63.3%) and harmful habits (excessive caffeine intake — up to 30%, alcohol — up to 25%, smoking — up to 30%), along with a lack of awareness regarding their impact on reproductive health. No significant difference in body mass index was found between women with and without PTSD. The findings highlight the need to incorporate preventive, educational, and psychotherapeutic strategies into the clinical management of women with RPL and PTSD.

Conclusion. Lifestyle is a significant modifiable factor in the development of RPL in women with PTSD. Implementation of multidisciplinary lifestyle correction programs is advisable as part of comprehensive therapy.

References

1. Śmigielska-Mikołajczyk M.J., Szostak A., Szeliga A. et al. (2024) The influence of lifestyle on female fertility. Review of the literature. Quality in Sport, 21: 53937.
2. Nichols A.R., Chavarro J.E., Oken E. (2024) Reproductive risk factors across the female lifecourse and later metabolic health. Cell Metabolism, 36(2): 240–262.
3. Ng K.Y.B., Cherian G., Kermack A.J. et al. (2021) Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss. Sci. Rep., 11(1): 7081. doi.org/10.1038/s41598-021-86445-2.
4. American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders: DSM-5. Am. Psychiatr. Publ., 991 р.
5. Michopoulos V., Vester A., Neigh G. (2016) Posttraumatic stress disorder: A metabolic disorder in disguise? Experimental neurology, 284 (Pt B): 220–229.
6. The ESHRE Guideline Group on R.P.L., Atik R.B., Christiansen O.B., Elson J. et al. (2023) ESHRE guideline: recurrent pregnancy loss: an update in 2022. Human Reproduction Open, 2023(1): hoad002. DOI:10.1093/hropen/hoad002.
7. Toth B., Bohlmann M., Hancke K. et al. (2022) Recurrent Miscarriage: Diagnostic and Therapeutic Procedures. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry № 015/050, May 2022). Geburtshilfe und Frauenheilkunde, 83(1): 49–78. doi.org/10.1055/a-1895-9940.
8. Наказ МОЗ України від 03.11.2008 р. № 624 «Про внесення змін до наказу МОЗ України від 15 грудня 2003 року». Клінічний протокол «Невиношування вагітності». zakon.rada.gov.ua/rada/show/v0624282-08#Text.
9. Stefanidou E.M., Caramellino L., Patriarca A., Menato G. (2011) Maternal caffeine consumption and sine causa recurrent miscarriage. Eur. J. Obstetr. Gynecol. Reproduct. Biol., 158(2): 220–224.
10. Kachadourian L.K., Pilver C.E., Potenza M.N. (2014) Trauma, PTSD, and binge and hazardous drinking among women and men: findings from a national study. J. Psychiatr. Res., 55: 35–43. doi.org/10.1016/j.jpsychires.2014.04.018.
11. Koert E., Malling G.M.H., Sylvest R. et al. (2019) Recurrent pregnancy loss: couples’ perspectives on their need for treatment, support and follow up. Human reproduction (Oxford, England), 34(2): 291–296. doi.org/10.1093/humrep/dey362.