Afosil is a complex solution for the harmonious operation of the hepatobiliary system

July 4, 2024
772
УДК:  616.36-003
Specialities :
Resume

Cholestasis is a condition characterized by a violation of the bile outflow, which can cause various pathological changes in the liver and biliary tract. In the treatment of cholestasis, an integrated approach is important, which allows to reduce the severity of the symptoms of the disease, prevent the development of complications and improve the general condition of the patient. In the complex treatment of cholestasis, a significant place belongs to plant extracts, which is connected with their natural properties. The biological supplement Afosil is widely available on the pharmaceutical market of Ukraine, which includes dry artichoke leaf extract, silybin-phosphatidylcholine complex, vitamin E, black pepper extract containing 95% piperine. Dry extract of artichoke leaves has choleretic, hepatoprotective, antioxidant properties, and also helps to remove harmful substances, nitrogen-containing compounds (urea, creatinine) from the body and lower cholesterol levels. The silybin-phosphatidylcholine-vitamin E complex has a complex effect that promotes the recovery of liver cells, improves their stability and protects against toxic damage. Afosil also contains black pepper extract containing piperine, which has potential pharmacological properties, including anti-inflammatory, antimicrobial and hepatoprotective effects. Thus, cholestasis is a complex problem that requires a comprehensive approach to treatment, which will allow not only to reduce the symptoms of the disease, but also to prevent the development of serious complications.

References

  • 1. Ignazio Grattagliano et al. How best to manage chronic cholestasis. J Fam Pract. 2018; 67(7): E9–E15.
  • 2. Galia Pollock, Gerald Y. Minuk. Diagnostic considerations for cholestatic liver disease. J. Gastroenterol. Hepatol. 2017; 32(7): 1303–1309. doi: 10.1111/jgh.13738.
  • 3. Fernanda Q. Onofrio, Gideon M. Hirschfield. The pathophysiology of cholestasis and its relevance to clinical practice. Clin. Liver Dis. (Hoboken). 2020; 15(3): 110–114. doi: 10.1002/cld.894.
  • 4. E. Jenny Heathcote. Diagnosis and management of cholestatic liver disease. Clin. Gastroenterol. Hepatol. 2007; 5: 776–782. doi: 10.1016/j.cgh.2007.05.008.
  • 5. Phillips J.R. et al. Fat-soluble vitamin levels in patients with primary biliary cirrhosis. Am. J. Gastroenterol. 2001; 96: 2745–2750. doi: 10.1111/j.1572-0241.2001.04134.x.
  • 6. Cynthia Levy, Keith D. Lindor. Management of osteoporosis, fat-soluble vitamin deficiencies, and hyperlipidemia in primary biliary cirrhosis. Clin. Liver Dis. 2003; 7: 901–910. doi: 10.1016/s1089-3261(03)00097-7.
  • 7. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of cholestatic liver diseases. J. Hepatol. 2009; 51: 237–267. doi: 10.1016/j.jhep.2009.04.009.
  • 8. Lungen Lu, Chinese Society of Hepatology and Chinese Medical Association. Guidelines for the Management of Cholestatic Liver Diseases. J. Clin. Transl. Hepatol. 2022; 10(4): 757–769. doi: 10.14218/JCTH.2022.00147.
  • 9. Марушко Ю.В., Хомич О.В. Застосування рослинних засобів для покращення функціональної діяльності печінки та жовчного міхура. Сімейна медицина. Європейські практики. 2023; 3: 77–84.
  • 10. Росул М.Я.М., Корабельщикова М.О., Іваньо Н.В. (2015) Артишок: можливості і перспективи застосування в клінічній практиці. Сучасні аспекти збереження здоров’я людини: матеріали міжнар. міждисциплінарної наук.-практ. конф., сан. «Квітка полонини», 17–18 квітня 2015 р., 199–202.
  • 11. Sae´nz Rodriguez T., Garcı´a Gime´nez D., a Va´zquez R. Choleretic activity and biliary elimination of lipids and bile acids induced by an artichoke extract in rats. Phytomedicine. 2002; 9: 687–693. doi: 10.1078/094471102321621278.
  • 12. Vincenzo Lattanzio et al. Globe artichoke: A functional food and source of nutraceutical ingredients. 2009; 1(2): 131–144. doi: 10.1016/j.jff.2009.01.002.
  • 13. Ewa Florek et al. Evaluation of the Protective and Regenerative Properties of Commercially Available Artichoke Leaf Powder Extract on Plasma and Liver Oxidative Stress Parameters. Antioxidants. 2023; 12(10): 1846. doi: 10.3390/antiox12101846.
  • 14. Vladimír Kren, Daniela Walterová. Silybin and silymarin-new effects and applications. Biomed papers. 2005; 149(1): 29–41.
  • 15. F. Fraschini et al. Pharmacology of silymarin. Clinical drug investigation, 2002; 22: 51–65.
  • 16. Wina Maryana et al. Formation of phytosome containing silymarin using thin layer-hydration technique aimed for oral delivery. Materials today: proceedings. 2016; 3(3): 855–866.
  • 17. Ludovico Abenavoli et al. Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. Phytother Res. 2018; 32(11): 2202–2213. doi: 10.1002/ptr.6171.
  • 18. Maret Traber, Jeffrey Atkinson. Vitamin E, antioxidant and nothing more. Free radical biology and medicine. 2007; 43(1): 4–15. doi: 10.1016/j.freeradbiomed.2007.03.024.
  • 19. Mittal R., Gupta R.L. In vitro antioxidant activity of piperine. Methods and findings in experimental and clinical pharmacology. 2000; 22(5): 271–274. doi: 10.1358/mf.2000.22.5.796644.