The place of modern phytotherapy in the treatment of urinary tract infections | Ukrainian Medical Journal

According to current recommendations, antimicrobial agents are the gold standard for treating urinary tract infections (UTI). However, their use is associated with the development of several side effects, including the development of antimicrobial resistance and disruption of normal intestinal flora, which necessitates the search for alternative treatment methods for UTI. Plant extracts and herbs are known for their natural antimicrobial, anti-inflammatory, and diuretic properties, which can be beneficial in the treatment of such infections. A series of scientific studies provide data on the benefits of cranberry extract, goldenrod herb, field horsetail, and lovage in reducing the severity of UTI symptoms and preventing further recurrences. Thus, phytotherapy is a promising direction in the treatment of UTI, indicating the need for further scientific research in this area.

References

1. Tan C.W., Chlebicki M.P. (2016) Urinary tract infections in adults. Singapore Med. J., 57(9): 485.
2. Wagenlehnerb D.S.B.F., Höllerc M., Kurt D.A.S.H.S., Naberd G. (2023) Phytotherapy (BNO 1045) of acute lower uncomplicated urinary tract infection in women normalizes local host responses. Urol. Int., 107: 778–784.
3. Ferreira T.S., Moreira C.Z., Cária N.Z. et al. (2014) Phytotherapy: an introduction to its history, use and application. Rev. bras. plantas med., 16(2).
4. Liu S.W., Guo J., Wu W.K. et al. (2019) Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial. Chin. J. Integr. Med., 25(1): 16–22. doi: 10.1007/s11655-017-2960-4.
5. Cai T., Cocci A., Tiscione D. et al. (2018) L-Methionine associated with Hibiscus sabdariffa and Boswellia serrata extracts are not inferior to antibiotic treatment for symptoms relief in patients affected by recurrent uncomplicated urinary tract infections: Focus on antibiotic-sparing approach. Arch. Ital. Urol. Androl., 90(2): 97–100.
6. Maki K.C., Kaspar K.L., Khoo C. et al. (2016) Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection. Am. J. Clin. Nutr., 103(6): 1434–1442.
7. Takahashi S., Hamasuna R., Yasuda M. et al. (2013) A randomized clinical trial to evaluate the preventive effect of cranberry juice (UR65) for patients with recurrent urinary tract infection. J. Infect. Chemother., 19(1): 112–117. doi: 10.1007/s10156-012-0467-7.
8. Beerepoot M.A., ter Riet G., Nys S. et al. (2011) Cranberries vs antibiotics to prevent urinary tract infections: a randomized double-blind noninferiority trial in premenopausal women. Arch. Intern. Med., 171: 1270–1278.
9. Koradia P., Kapadia S., Trivedi Y. et al. (2019) Probiotic and cranberry supplementation for preventing recurrent uncomplicated urinary tract infections in premenopausal women: a controlled pilot study. Expert Rev. Anti. Infect Ther., 17: 733–740.
10. El Menyiy N., Guaouguaou F.E., El Baaboua A. et al. (2021) Phytochemical properties, biological activities and medicinal use of Centaurium erythraea Rafn. J. Ethnopharmacol., 276: 114171.
11. Haloui M., Louedec L., Michel J.B. et al. (2000) Experimental diuretic effects of Rosmarinus officinalis and Centaurium erythraea. J. Ethnopharmacol., 71(3): 465–472.
12. Carneiro D.M., Jardim T.V., Araújo Y.C.L. et al. (2019) Equisetum arvense: new evidences supports medical use in daily clinic. Pharmacogn. Rev., 13: 50–58.
13. Carneiro D.M., Freire R.C., Honório T.C.D.D. et al. (2014) Randomized, double-blind clinical trial to assess the acute diuretic effect of Equisetum arvense (field horsetail) in healthy volunteers. Evid. Based Complement. Alternat. Med., 760683.
14. Jakubczyk A., Złotek U., Rybczyńska-Tkaczyk K. (2021) Influence of Elicitation and Drying Methods on Anti-Metabolic Syndrome, and Antimicrobial Properties of Extracts and Hydrolysates Obtained from Elicited Lovage (Levisticum officinale Koch). Nutrients, 13(12): 4365. doi: 10.3390/nu13124365.
15. Deipenbrock M., Scotti F., Mo B. et al. (2023) Seven-day oral intake of orthosiphon stamineus leaves infusion exerts antiadhesive ex vivo activity against uropathogenic E. coli in urine samples. Planta Med., 89(08): 778–789.