Neuropathic pain: clinically important aspects of pregabalin in questions and illustrated answers | Ukrainian Medical Journal

Neuropathic pain is a common feature of various diseases; NSAIDs are not able to relieve it. Gabapentinoids, in particular pregabalin, are the first line of treatment for neuropathic pain. Pregabalin has an extensive evidence base of efficacy and safety in the treatment of neuropathic pain of various genesis; pregabalin is recommended for use by leading international societies with a stepwise increase in dosage from the initiating dose (150 mg/day) to reaching maintenance doses (300 or 600 mg/day). The likelihood of developing serious side effects with pregabalin does not differ from that of placebo. Pregabalin is a highly effective drug for the treatment of neuropathic pain, which has some potential side effects, the likelihood of which increases significantly in case of self-medication, abuse, and overdose; which requires mandatory prescription of the drug and careful prescription to persons at risk.

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