Study of аssociations between early depression or anxiety and subsequent risk of coronary heart disease: is there strong evidence?

Anxiety and depression are common illnesses. The armed invasion of the Russian Federation led to an increase in the frequency of their development in Ukrainian society. Often, depressive and anxiety states are observed in isolation, but sometimes they are combined with various cardiovascular disorders. The article presents the results of search for a connection between disorders of the psycho-emotional state in young people and the occurrence of serious cardiac diseases in age older than 36–38 years. An analysis of a long-term Swedish study was carried out, where 49.321 young men aged 18–20 before their conscription for military service were surveyed. The obtained results showed a weak and statistically insufficient correlation between early manifestations of depression in young men and the subsequent development of coronary heart disease in older men. In contrast to depression, the presence of anxiety was strongly associated with the future development of coronary heart disease over the next four decades. The relative risk of long-term hospitalization for coronary heart disease and acute myocardial infarction in young men with depressive symptoms was 1.18 (95% confidence interval (CI) 0.80–1.75) and 1.20 (95% CI 0.75–1.90), respectively. For anxiety, similar indicators were 2.44 (95% CI 1.44–4.14) and 2.82 (95% CI 1.56–5.11), respectively.

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