Hypertension and symptoms dynamics following hospitalization for COVID-19: the results of a 12-months follow-up

January 12, 2024
УДК:  616.12-008.331.1:616.98:578.834.1COVID-19]-036»450*1»

The article presents the results of a 12-month observational study of the dynamics of natural resolution of physical, respiratory, and cognitive symptoms following hospitalization for COVID-19, depending on the presence of hypertension.

Material and methods. 221 hospitalized patients with COVID-19 (mean age 53.4±13.6 years; 53% women) were surveyed 1–2 days before discharge, after 1, 3 and 12 months using the MRC Dyspnea scale, CAT and CCQ questionnaires, the physical symptoms subscale of the EFTER-COVID questionnaire, and the Memory, Thinking, and Communication subscale of the SBQ-LC questionnaire.

Results. Hospitalized CO­VID-19 patients with a history of hypertension showed similar trends in resolution of physical and cognitive symptoms during the 12-month follow-up period, but had higher levels of residual respiratory symptoms and dyspnea compared to normotensive participants, while the latter were characterized by significantly higher levels of new cognitive symptoms as assessed by the corresponding SBQ-LC questionnaire subscale.

Conclusion. History of hypertension was associated with specific phenotypic features of the post-covid syndrome and can be used to create predictive models of its development.


  • 1. Covid-19 Excess Mortality Collaborators. Estimating excess mortality due to the CO­VID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21. Lancet. 2022; 399: 1513–1536. doi.org/10.1016/S0140-6736(21)02796-3.
  • 2. Delardas O., Kechagias K.S., Pontikos P.N., Giannos P. (2022) Socio-Economic Impacts and Challenges of the Coronavirus Pandemic (COVID-19): An Updated Review. Sustainability, 14. doi.org/10.3390/su14159699.
  • 3. Doroftei B., Ciobica A., Ilie O.D. et al. (2021) Mini-Review Discussing the Reliability and Efficiency of COVID-19 Vaccines. Diagnostics (Basel), 11. doi.org/10.3390/diagnostics11040579.
  • 4. www.worldometers.info/coronavirus/worldwide-graphs/.
  • 5. Astin R., Banerjee A., Baker M.R. et al. (2023) Long COVID: mechanisms, risk factors and recovery. Exp. Physiol., 108: 12–27. doi.org/10.1113/EP090802.
  • 6. Gyongyosi M., Alcaide P., Asselbergs F.W. et al. (2022) Long COVID and the cardiovascular system — elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: A joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial & Pericardial Di­seases. Cardiovasc. Res. doi.org/10.1093/cvr/cvac115.
  • 7. NICE (2022) COVID-19 rapid guideline: managing the long-term effects of COVID-19. In: COVID-19 rapid guideline: managing the long-term effects of COVID-19.
  • 8. Tran V.T., Porcher R., Pane I., Ravaud P. (2022) Course of post COVID-19 disease symptoms over time in the ComPaRe long COVID prospective e-cohort. Nat. Commun., 13: 1812. doi.org/10.1038/s41467-022-29513-z.
  • 9. Carfi A., Bernabei R., Landi F. et al. (2020) Persistent Symptoms in Patients After Acute COVID-19. JAMA, 324: 603–605. doi.org/10.1001/jama.2020.12603.
  • 10. World Health Organization (WHO) (2021) COVID-19 Clinical management: living guidance, 25.01.2021. http://www.who.int/publications/i/item/WHO-2019-nCoV-clinical-2021-1.
  • 11. Laboratories ATSCoPSfCPF (2002) ATS statement: guidelines for the six-minute walk test. Am. J. Respir. Crit. Care Med., 166: 111–117. doi.org/10.1164/ajrccm.166.1.at1102.
  • 12. Mahler D.A., Wells C.K. (1988) Evaluation of clinical methods for rating dyspnea. Chest, 93: 580–586. doi.org/10.1378/chest.93.3.580.
  • 13. Jones P.W., Harding G., Berry P. et al. (2009) Development and first validation of the COPD Assessment Test. Eur. Respir. J., 34: 648–654. doi.org/10.1183/09031936.00102509.
  • 14. van der Molen T., Willemse B.W., Schokker S. et al. (2003) Development, validity and responsiveness of the Clinical COPD Questionnaire. Health Qual Life Outcomes, 1: 13. doi.org/10.1186/1477-7525-1-13.
  • 15. Sorensen A.I.V., Spiliopoulos L., Bager P. et al. (2022) A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark. Nat. Commun., 13: 4213. doi.org/10.1038/s41467-022-31897-x.
  • 16. Hughes S.E., Haroon S., Subramanian A. et al. (2022) Development and validation of the symptom burden questionnaire for long covid (SBQ-LC): Rasch analysis. BM, 377: e070230. doi.org/10.1136/bmj-2022-070230.