Changes in biochemical blood parameters of patients of two age groups at stage IV of osteoarthrosis of the knee joint

January 9, 2024
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УДК:  616.72-018.3:615.2/3:577.121
Resume

23 women who were diagnosed with stage IV bilateral gonarthrosis in the previous stages took part in the study. The average age of the patients of the 1st group was 64.44±1.02, the 2nd — 75.00±1.63. Blood serum was used as the research material. In it, the concentration of calcium, phosphorus and the activity of alkaline phosphatase were determined using standard «Roche Diagnostics» test systems on a «Cobas-311» biochemical analyzer. The concentration of osteocalcin, parathyroid hormone, and procollagen II N-terminal propeptide was determined by the enzyme immunoassay method on the «Cobas-411» enzyme immunoassay using «Roche Diagnostics» test systems. According to the results of a biochemical study of blood serum of patients of both age groups with bilateral gonarthrosis of the knee joint stage IV, the concentrations of osteocalcin and parathyroid hormone were moderately changed, which allows us to use these biochemical tests to characterize the last stage of the disease. An increase in the concentration of osteocalcin and a decrease in parathyroid hormone at the IV stage of gonarthrosis of the knee joint reflects metabolic disorders, especially for the age group of 75.00±1.63.

References

  • 1. Bestwick-Stevenson T., Wyatt L.A., Palmer D. et al. (2021) Incidence and risk factors for poor ankle functional recovery, and the development and progression of posttraumatic ankle osteoarthritis after significant ankle ligament injury (SALI): the SALI cohort study protocol. BMC Musculoskel. Dis., 22(1): 362. doi.org/10.1186/s12891-021-04230-8.
  • 2. Godoy-Santos A.L., Fonseca L.F., de Cesar Netto C. et al. (2020) Ankle Osteoarthritis. Revista brasileira de ortopedia, 56(6): 689–696. doi.org/10.1055/s-0040-170973.
  • 3. Briggs A.M., Woolf A.D., Dreinhöfer K. et al. (2018) Reducing the global burden of musculoskeletal conditions. Bull. World Health Organization, 96(5): 366–368.
  • 4. Magnusson K., Turkiewicz A., Englund M. (2019) Nature vs nurture in knee osteoarthritis — the importance of age, sex and body mass index. Osteoarthritis Cartilage, 27(4): 586–592.
  • 5. Kijowski R., Demehri S., Roemer F., Guermaz A. et al. (2020) Osteoarthritis year in review 2019: imaging. Osteoarthritis Cartilage, 28(3): 285–295.
  • 6. Luyten F.P., Bierma-Zeinstra S., Dell’Accio F., Kraus V.B. (2018) Toward Classification Criteria for Early Osteoarthritis of the Knee. Semin. Arthritis Rheum., 47 (4): 457–463. DOI: 10.1016/j.semarthrit.2017.08.006.
  • 7. Magomedov S., Osadchuk T., Zazizrnyy I., Kuzub T. et al. (2021) Biochemical changes of the connective tissue metabolism in patients with knee osteoarthrosis. Bull. Georg. Nati. Acad. Sci., 15(3): 97–102.
  • 8. Hu N., Zhang J., Wang J. et al. (2022) Biomarkers of Joint Metabolism and Bone Mineral Density Are Associated with Early Knee Osteoarthritis in Premenopausal Females. Clin. Rheumatol., 41(3): 819–829. DOI: 10.1007/s10067-021-05885-3.
  • 9. Nagy E.E., Nagy-Finna C., Popoviciu H., Kovács B. (2020) Clin. Interv. Aging, 15: 501–518. doi: 10.2147/CIA.S242288.
  • 10. Mahon O.R., Kelly D.J., McCarthy G.M., Dunne A. (2020) Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization. Osteoarthritis and Cartilage, 28(5): 603–612.
  • 11. Bondarenko S.E., Leontieva F.S., Vysotsky O.V. et al. (2020) Biochemical Markers of Blood Serum in Patients at Different Stages of Hip and Knee Osteoarthritis. Ukr. J. Med. Biol. Sports, 5(3): 173–178.
  • 12. Donell S. (2019) Subchondral Bone Remodelling in Osteoarthritis. EFORT Open Rev., 4(6): 221–229. DOI: 10.1302/2058-5241.4.180102.
  • 13. Zhu X., Chan Y.T., Yung P.S.H. et al. (2021) Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis. Front. Cell Dev. Biol., 8. Art. № 607764. DOI: 10.3389/fcell.2020.607764
  • 14. Jiang A., Xu P., Sun S. et al. (2021) Cellular alterations and crosstalk in the osteochondral joint in osteoarthritis and promising therapeutic strategies. Connect Tissue Res., 62(6): 709–719. DOI: 10.1080/03008207.2020.1870969.
  • 15. Zhang G., Yin C., Wu R. et al. (2022) A gene expression analysis and immune infiltration between lesioned and preserved subchondral bone in osteoarthritis. BioRxiv. 2022.09.12.507705. DOI: 10.1101/2022.09.12.507705.