Changes in biochemical blood parameters of patients of two age groups at stage IV of osteoarthrosis of the knee joint | Ukrainian Medical Journal

23 women who were diagnosed with stage IV bilateral gonarthrosis in the previous stages took part in the study. The average age of the patients of the 1st group was 64.44±1.02, the 2nd — 75.00±1.63. Blood serum was used as the research material. In it, the concentration of calcium, phosphorus and the activity of alkaline phosphatase were determined using standard «Roche Diagnostics» test systems on a «Cobas-311» biochemical analyzer. The concentration of osteocalcin, parathyroid hormone, and procollagen II N-terminal propeptide was determined by the enzyme immunoassay method on the «Cobas-411» enzyme immunoassay using «Roche Diagnostics» test systems. According to the results of a biochemical study of blood serum of patients of both age groups with bilateral gonarthrosis of the knee joint stage IV, the concentrations of osteocalcin and parathyroid hormone were moderately changed, which allows us to use these biochemical tests to characterize the last stage of the disease. An increase in the concentration of osteocalcin and a decrease in parathyroid hormone at the IV stage of gonarthrosis of the knee joint reflects metabolic disorders, especially for the age group of 75.00±1.63.

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