Cognitive and psychoemotional disorders in patients with different forms of Lyme borreliosis

Malysh T.Yu.,Trishchynska M.A.

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Cognitive and psychoemotional disorders in patients with different forms of Lyme borreliosis

January 23, 2023

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Neurology and Psychiatry

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Neurology and Psychiatry

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The purpose of the work is to study the prevalence and characteristics of cognitive and emotional disorders in patients with various forms of Lyme borreliosis. We conducted a case-control study. 48 patients (33 women, 15 men) were examined. For each patient, 38«matched» controls were selected, matched by gender, age (±5 years), nationality, and place of birth. The Mini-Mental State Examination and the Montreal Scale of Cognitive Assessment were used to assess cognitive function. Assessment of affective disorders was carried out using the Hospital Anxiety and Depression Scale (HADS). It was established that Lyme borreliosis is associated with the risk of developing of cognitive disorders (odds ratio (OR) 2.35; 95% confidence interval (CI) 1.03–5.33), clinically expressed anxiety (>11 points on the HADS) (OR 7.53; 95% CІ 2.82–20.14) and clinically expressed depression (OR 17.46; 95% CI 2.09–139.5). Cognitive disorders were significantly more common in patients with neuroborreliosis (OR 12.48; 95% CI 3.03–51.41; р<0.001). In patients of the neuroborreliosis subgroup, clinically expressed anxiety (>11 HADS points) was found in 25 (80.6%) and clinically expressed depression in 12 (38.7%) cases, while in all patients without neurological symptoms, and only 2 (28.6%) patients without neurological symptoms had clinically expressed anxiety (OR 31.26; 95% CІ 5.58–175.1; р<0.001), and 1 (5.9%) — clinically expressed depression (OR 10.11; 95% CІ 1.18–86.37; р=0.014).

References

1. Фурик О.О., Рябоконь О.В., Задирака Д.А. та ін. (2021) Клінічні особливості Лайм-бореліозу у Запорізькій області за період 2015–2019 рр. Актуальна інфектологія, 9(1): 89.
2. Шестакович-Корецька Л.Р., Будаєва І.В., Чергінець А.В. та ін. (2014) Лайм-бореліоз: питання діагностики та терапії. Актуальна інфектологія, 2(3): 34–38.
3. Трускавецька І.Я. (2017) Епідеміологічні особливості при укусі іксодових кліщів (Ixodidae). Молодий вчений, 9.1 (49.1): 171–174.
4. Ілляш Т.І. (2018) Діагностичні проблеми нейробореліозу. Укр. неврол. журн., 2: 5–10.
5. Карпов И.А., Соловей Н.В., Анисько Л.А. и др. (2015) Лайм-боррелиоз: вопросы диагностики и рациональной этиотропной терапии. Клин. инфектол. паразитол., 3(14): 64–80.
6. Schwenkenbecher P., Pul R., Wurster U. et al. (2017) Common and uncommon neurological manifestations of neuroborreliosis leading to hospitalization. BMC Infect. Dis., 17(1): 90. DOI: 10.1186/s12879-016-2112-z.
7. Баранова Н.С., Спирин Н.Н., Низовцева Л.А. и др. (2012) Клинико-инструментальная характеристика хронических форм нейроборрелиоза. Журн. неврол, психиатр., 9(2): 40–47.
8. Oczko-Grzesik B., Kępa L., Puszcz-Matlińska M. et al. (2017) Estimation of cognitive and affective disorders occurrence in patients with Lyme borreliosis. Ann. Agric. Environ. Med., 24(1): 33–38. DOI: 10.5604/12321966.1229002.
9. Cairns V. (2005) Post-Lyme borreliosis syndrome: a meta-analysis of reported symptoms. Int. J. Epidemiol., 34(6): 1340–1345. DOI: 10.1093/ije/dyi129.
10. Fallon B.A., Keilp J.G., Corbera K.M. et al. (2008) A randomized, placebo-controlled trial of repeated iv antibiotic therapy for Lyme encephalopathy. Neurology, 70(13): 992–1003. DOI: 10.1212/01.WNL.0000284604.61160.2d.
11. Eikeland R., Ljostad U., Mygland A. et al. (2012) European neuroborreliosis: neuropsychological findings 30 months post-treatment. Eur. J. Neurol., 19(3): 480–487. DOI: 10.1111/j.1468-1331.2011.03563.x.
12. Talarowska M., Florkowski A., Gałecki P. et al. (2009) Cognitive function and depression. Psychiatr Pol., XLIII(1): 31–40.
13. Баранова Н.С., Спирин Н.Н., Шипова Е.Г., Степанов И.О. (2010) Поражение нервной системы на отдаленных стадиях Лайм-боррелиоза. Журн. неврол. психиатр., 110(2): 90–96.
14. Folstein M.F., Folstein S.E., McHugh P.R. (1975) «Mini-mental state». A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res., 12(3): 189–198. DOI: 10.1016/0022-3956(75)90026-6.
15. Nasreddine Z.S., Phillips N.A., Bédirian V. et al. (2005) The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J. Am. Geriatr. Soc., 53(4): 695–699. DOI: 10.1111/j.1532-5415.2005.53221.x.
16. Zigmond A.S., Snaith R.P. (1983) The Hospital Anxiety And Depression Scale. Acta. Psychiatr. Scand., 67(6): 361–370. DOI: 10.1111/j.1600-0447.1983.tb09716.x.
17. Lantos P.M., Rumbaugh J., Bockenstedt L.K. et al. (2021) Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Arthritis Care Res (Hoboken), 73 (1): 1–9. DOI: 10.1002/acr.24495.