Extrapontine myelinolysis: features of one clinical observation

March 23, 2023
Specialities :

We present the actual clinical observation of the detected case of extrapontine myelinolysis in a patient with discirculatory hypertensive and dysmetabolic encephalopathy and chronic kidney disease with courses of hemodialysis. The course of the disease, clinical symptoms, diagnostic measures and treatment tactics were carried out.


  • 1. Wright D.G., Laureno R., Brain M.V. (1979) Pontine and extrapontine myelinolysis. Brain, p. 102. DOI: 10.1093/brain/102.2.361.
  • 2. Gocht A., Colmant H.J. (1987) Central pontine and extrapontine myelinolysis: a report of 58 cases. Clin. Neuropathol., 6(6): 262–270.
  • 3. Salvesen R. (1998) Extrapontine myelinolysis after surgical removal of a pituitary tumour. Acta Neurol. Scand., 46–48 p. DOI: 10.1111/j.1600-0404.1998.tb07297.x.
  • 4. Stetkarova I., Svobodova Z., Soltez J., Svatova J. (2016) Extrapontine myelinolysis manifested selectively by acute severe parkinsonian syndrome. Case Report. Neuro Endocrinol. Lett., 37(6): 415–418.
  • 5. Coça K.L., Bergmann A., Ferman S. et al. (2017) Speech, swallowing and quality of life outcomes in extrapontine myelinolysis: a case report of a teenager with central nervous system germ cell tumor. CEFAC, p. 28.
  • 6. Rehman M.A.U., Abdulrahman A.F., Zainab A. et al. (2021) Hyponatremia and extrapontine myelinolysis in a patient with COVID-19: a case report. Wiley Online Library, p. 16.
  • 7. Bonkowsky J.L., Filloux F. (2003) Extrapontine Myelinolysis in a Pediatric Case of Diabetic Ketoacidosis and Cerebral Edema. J. Child Neurol., 18: 144–147.
  • 8. Zunga P.M., Farooq O., Dar M.I. et al. (2015) Extra pontine osmotic demyelination syndrome. Ann. Neurosci., 22(1): 51–53. DOI: 10.5214/ans.0972.7531.220212.
  • 9. Lee C., Ko C. (2021) Temporal Brain MRI Changes From Extrapontine Myelinolysis to Central Pontine Myelinolysis: a Case Report. Cureus, p. 13–15.
  • 10. Martin R.J. (2004) Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes. J. Neurol. Neurosurg. Psychiatr., 75(suppl. 3): iii22–iii28.
  • 11. Oya S., Tsutsumi K., Ueki K., Kirino T. (2001) Reinduction of hyponatremia to treat central pontine myelinolysis. Neurology, p. 22. DOI: 10.1212/wnl.57.10.1931.
  • 12. Krishnan G.D., Krishnan D., Khet F.Y., Kang C.Y. (2019) Plasmapheresis to treat osmotic demyelination syndrome from overly rapid plasma sodium correction. Med. J. Malaysia, p. 44–45. DOI: 10.1159/000521814.
  • 13. Wijesundara D., Senanayake B. (2022) Plasmapheresis for Extrapontine Myelinolysis: a Case Series and a Literature Review. Case Rep. Neurol., p. 12.
  • 14. Karp B.I., Laureno R. (2000) Central pontine and extrapontine myelinolysis after correction of hyponatraemia. The Neurologist, p. 62.