Peculiarities of pharmacological correction of somatic manifestations of depression and cognitive decline in patients with anxiety-depressive disorders during wartime

November 1, 2022
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The high prevalence of depression in the world and in Ukraine in particular and also the growing prevalence of anxiety-depressive disorders in our country during the war makes relevant the question of pharmacological correction of neuropathic pain and depression-associated cognitive decline. The purpose of this review is to analyze current literature data on the mechanism of action of duloxetine and the results of systematic reviews, meta-analyses, randomized clinical trials on the its ability to improve the somatic manifestations of anxiety-depressive disorders, neuropathic pain and cognitive functions. The combination of anti-anxiety, antidepressant, analgesic effect and own procognitive activity together with the combined mechanism of action, good safety profile, satis­factory tolerability makes duloxetine a promising drug for correcting somatic manifestations of anxiety-depressive disorders, neuropathic pain, chronic postoperative pain, fibromyalgia, diabetic peripheral neuropathic pain, osteoarthritis of knee joints. Among the large number of antidepressants, duloxetine has a direct analgesic and its own procognitive effect, which makes it possible to include it in a multimodal postoperative analgesic protocol for the management of patients with combat surgical trauma. The cost-effectiveness of duloxetine emphasizes the feasibility of its use even without additional screening for depression.

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