Characteristics of hemodynamic parameters and quality of life in patients with stable angina with postinfarction cardiosclerosis with available risk factors and different variants of heart failure

August 26, 2022
928
Specialities :
Resume

The aim was to assess hemodynamic, laboratory and instrumental indicators and quality of life and to conduct quantitative analysis of risk factors in patients with stable angina (SA) with postinfarction cardiosclerosis (PIC) and various variants of heart failure.

Object and methods of research. The study involved 28 patients with SA II–III functional class with PIC (1st group; mean age 56.8±6.7 years; 72.8% of men and 27.2% of women) and 32 patients with SA II–III functional class without PIC (2nd group; average age 52.3±4.2 years; 62.5% of men and 37.5% of women). The observation lasted for 6 months.

Results. In patients with SA and PIC (1st group) such risk factors as: smoking, type 2 diabetes, hypercholesterolemia predominate over patients with SA without PIC (2nd group) (p<0.05), except for hypertension, which in the 2nd group is significantly higher by 7% than in the 1st group (p<0.05). In all patients with type 2 diabetes diastolic dysfunction (DD) type I prevailed (1st group 68.75%, 2nd group 66.60%). Hemodynamic parameters in patients during the 6-month follow-up were significantly lower in the group with SA without PIC compared with the group with SA with PIC. Quality of life according to the Minnesota Living with Heart Failure Questionnaire and Seattle Angina Questionnaire is significantly worse in patients with SA and PIC than in patients with SA without PIC. When conducting an echocardiographic examination, it was found that DD type 1 and type 2 were more often observed in patients of the 1st group (12 (42.8%) and 13 (46.4%) patients, respectively). DD type 1 was significantly more common in the 2nd group (22 (68.75%) patients), while DD type 2 was present only in 9 (28%) patients (p<0.05).

References

  • 1. Knuuti J., Wijns W., Saraste A. et al. (2020) 2019 ESC guidelines on the diagnosis and management of chronic coronary syndromes: the task force for diagnosis and management of chronic coronary syndromes of the European society of cardiology (ESC). Eur. Heart J., 41(3): 407–477. doi:10.1093/eurheartj/ehz425.
  • 2. Ammirati E., Moroni F., Norata G.D. et al. (2015) Markers of Inflammation Associated with Plaque Progression and Instability in Patients with Carotid Atherosclerosis. Mediators of Inflammation, 15 p. http:// dx.doi.org/10.1155/2015/718329.
  • 3. International Diabetes Federation (2013) IDF Diabetes Atlas, 6th ed.
  • 4. Teodorovich N., Krakover R., Vered Z. (2008) B type natriuretic peptide: a universal cardiac biomarker. I.M.A.J., 10(2): 152–153.
  • 5. Salah K., Stienen S., Pinto Y., Tijssen J.G.P. (2019) Prognosis and NT-proBNP in heart failure patients with preserved versus reduced ejection fraction. Heart, 105(15): 1–8.
  • 6. Lam C.S.P., Gamble G.D., Ling L.H. et al. (2018) Mortality associated with heart failure with preserved vs. reduced ejection fraction in a prospective international multi-ethnic cohort study. Eur. Heart J., 39: 1770–1780.
  • 7. Murabito J.M., Evans J.C., Larson M.G., Levy D. (1993) Prognosis after the onset of coronary heart disease. An investigation of differences in outcome between the sexes according to initial coronary disease presentation. Circulation, 88: 2548–2555.