Safety profile of nimesulide. Reasonable assessment

The article discusses the therapeutic efficacy, clinical use and possible side effects of nimesulide, a member of the group of selective nonsteroidal anti-inflammatory drugs. A review of the literature on the safety profile of nimesulide has been made. Attention is paid to molecular mechanisms that increase the risk of hepatotoxicity of the drug. Ways to overcome the undesirable effects of nimesulide on hepatocytes are discussed.

References

1. Anderson J.J., Felson D.T. (1988) Factors associated with osteoarthritis of the knee in the first national Health and Nutrition Examination Survey (HANES I). Evidence for an association with overweight, race, and physical demands of work. Am. J. Epidemiol., 128(1): 179–189. doi: 10.1093/oxfordjournals.aje.a114939.
2. Bannuru R.R., Osani M.C., Vaysbrot E.E. et al. (2019) OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage, 27(11): 1578–1589. doi: 10.1016/j.joca.2019.06.011.
3. Bevilacqua M., Devogelaer J.P., Righini V. et al. (2004) Effect of nimesulide on the serum levels of hyaluronan and stromelysin-1 in patients with osteoarthritis: a pilot study. Int. J. Clin. Pract. Suppl., 200(144): 13–19.
4. Conforti A., Leone R., Mouretti U. et al. (2001) Adverse drug reactions related to the use of NSAIDs with a focus on nimesulide: results of spontaneous reporting from a Northern Italian area. Drug Saf., 24(14): 1081–1090. http//doi: 10.2165/00002018-200124140-00006.
5. Dillon C.F., Rasch E.K., Gu Q. et al. (2006) Prevalence of knee osteoarthritis in the United States: arthritis data from the third National Health and Nutrition Examination Survey 1991–1994. J. Rheumatol., 33: 2271–2279.
6. Dukuenne L., Chowdhuri R., Mankia K. et al. (2020) The Role of Ultrasound Across the Inflammatory Arthritis Continuum: Focus on «At-Risk» Individuals. doi.org/10.3389/fmed.2020.587827.
7. Felson D.T. (1990) The epidemiology of knee osteoarthritis: results from the Framingham Osteoarthritis Study. Semin. Arthritis Rheum., 20(3 Suppl. 1): 42–50. doi: 10.1016/0049-0172(90)90046-i.
8. Kaneko N., Kurata M., Yamamoto T. et al. (2019) The role of interleukin-1 in general pathology. Inflammation and Regeneration, 39: 12. doi.org/10.1186/s41232-019-0101-5.
9. Lapeyre-Mestre M., Grolleau S., Montastruc J.L. et al. (2013) Adverse drug reactions associated with the use of NSAIDs: a case/noncase analysis of spontaneous reports from the French pharmacovigilance database 2002-2006. Fundam. Clin. Pharmacol., 27(2): 223–230. doi: 10.1111/j.1472-8206.2011.00991.x.
10. Lawrence R.C., Felson D.T., Helmick C.G. et al. (2008) Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum., 58(1): 26–35. doi: 10.1002/art.23176.
11. Marwa K.A., Mohamed E.A., Sameh S.F. et al. (2012) The Effect of Nimesulide Compared to Other NSAIDs on Liver Functions in Children. Beni-Suef University Journal of Applied Sciences, 1(2): 26–31 (http://www.scopemed.org).
12. Mingato F.E., Dos Santos A.C., Rodrigues T. et al. (2002) Effects of nimesulide and its reduced metabolite on mitochondria. doi.org/10.1038/sj.bjp.0703667.
13. Moore N., Gilmez S.E., Larrey D. et al. (2013) Choice of the denominator in case population studies: event rates for registration for liver transplantation after exposure to NSAIDs in the SALT study in France. Pharmacoepidemiol. Drug Safety, 22(2): 160–167. doi: 10.1002/pds.3371.
14. Nevitt M.C., Lane N.E., Scott J.C. et al. (2005) Study of Osteoporotic Fractures Research Group. Radiographic osteoarthritis of the hip and bone mineral density. Arthritis Rheum., 38: 907–916. doi: 10.1002/art.1780380706.
15. Sengupta S., Velpandian T., Kabir S.R. et al. (1998) Analgesic efficacy and pharmacokinetics of topical nimesulide gel in healthy human volunteers: double-blind comparison with piroxicam, diclofenac and placebo. Eur. J. Clin. Pharmacol., 54(7): 541–547. doi: 10.1007/s002280050510.
16. Traversa G., Bianchi C., Da Gas R. et al. (2003) Cohort study of hepatotoxicity associated with nimesulide and other non-steroidal anti-inflammatory drugs. BMJ, 327(7405): 18–22. doi: 10.1136/bmj.327.7405.18.