Generation of reactive oxygen species in erythrocytes in patients with polytrauma and alcohol withdrawal complicated by alcoholic delirium

Omelchenko-Seliukova А.V.

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Generation of reactive oxygen species in erythrocytes in patients with polytrauma and alcohol withdrawal complicated by alcoholic delirium

February 15, 2022

1079

Oncology, Hematology

Orthopedics and Traumatology

Neurology and Psychiatry

Omelchenko-Seliukova А.V.

Keywords :

alcohol withdrawal syndrome,

alcoholic delirium,

dexmedetomidine,

polytrauma,

reactive oxygen species

Specialities :

Oncology, Hematology

Orthopedics and Traumatology

Neurology and Psychiatry

Resume

The last two decades have seen a global increase in alcohol abuse and the incidence of alcohol-related disorders. In turn, alcohol is a leading risk factor for many types of injuries. Alcohol withdrawal symptoms (AWS) occur in 31% of trauma patients. In patients with polytrauma and AWS, complicated by alcoholic delirium, there is an inflammatory process, one of the body’s responses to this pathological condition is the formation of reactive oxygen species (ROS) by neutrophils.

Aim: to determine the generation of ROS in the blood in patients with polytrauma and AWS with alcoholic delirium, depending on the method of sedation.

Materials and methods of the research. Eighty patients with moderate polytrauma and AWS complicated by alcoholic delirium were examined. The median age was 45 years. In patients of Group 1 (n=40) dexmedetomidine was chosen as the method of sedation, in Group 2 (n=40) sedation with diazepam according to the symptom-trigger protocol was used. The Confusion Assessment Method-Intensive Care Unit (CAM-ICU) method was used to diagnose delirium. Determination of ROS in erythrocytes was performed by flow cytometry using «BD FACSDiva^TM» software («Becton Dickinson», USA).

Results. In patients with polytrauma and AWS, complicated by alcoholic delirium significantly increased generation of ROS in erythrocytes was found, which promotes eryptosis.

Conclusion. The use of dexmedetomidine may be recommended as a sedative in the treatment of alcoholic delirium in patients with polytrauma and AWS.

References

1. World Health Organization (2019) Global status report on alcohol and health 2018.
2. Riuttanen A., Jäntti S.J., Mattila V.M. (2020) Alcohol use in severely injured trauma patients. Sci. Rep., 10(1): 17891. doi: 10.1038/s41598-020-74753-y.
3. Guinle M.I.B., Sinha R. (2020) The Role of Stress, Trauma, and Negative Affect in Alcohol Misuse and Alcohol Use Disorder in Women. Alcohol Res., 40(2): 5. doi: 10.35946/arcr.v40.2.05.
4. Mainerova B., Prasko J., Latalova K. et al. (2015) Alcohol withdrawal delirium — diagnosis, course and treatment. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc. Czech Repub., 159(1): 44–52. doi: 10.5507/bp.2013.089.
5. ASAM (2020) The ASAM Clinical Practice Guideline on Alcohol Withdrawal Management. J. Addict.Med., 14(3S Suppl. 1): 1–72. doi: 10.1097/ADM.0000000000000668.
6. Onishchenko A., Myasoedov V., Yefimova S. et al. (2021) UV Light-Activated GdYVO ₄:Eu³⁺ Nanoparticles Induce Reactive Oxygen Species Generation in Leukocytes Without Affecting Erythrocytes In Vitro. Biol. Trace Elem. Res. doi: 10.1007/s12011-021-02867-z.
7. Omelchenko-Seliukova A. (2021) The dynamic of indicators of lipid peroxidation and antioxidant protection status in patients with polytrauma and alcohol withdrawal syndrome complicated by alcohol delirium. World Sci., 11(72) https://doi.org/10.31435/rsglobal_ws/30122021/7729.
8. Vaschenko V.I., Vil’yaninov V.N. (2019) Eryptosis (quasi-apoptosis) the human red blood cells. Its role in medicinal therapy. Rev. Clin. Pharmacol. Drug Ther., 17(3): 5–38. doi: 10.17816/RCF1735-38.
9. Tkachenko A., Kot Y., Prokopyuk V. et al. (2021) Food additive E407a stimulates eryptosis in a dose-dependent manner. Wien Med. Wochenschr. doi: 10.1007/s10354-021-00874-2.