The problem of safety of pharmacotherapy of affective disorders: new opportunities

January 19, 2022
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The article considers the problem of finding effective pharmacotherapy of affective and, first of all, depressive disorders. Today, despite the wide choice of antidepressants and mood-stabilizers of different generations and with different types of action, the effectiveness of all strategies for the treatment of depression often remains unsatisfactory. It is noted that safety characteristics are a leading factor in the widespread introduction of the drug in clinical practice. The risks of side effects of the main groups of conventional antidepressants (tricyclic antidepressants, selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors) were assessed, including effects on the cardiovascular system, metabolic processes, sexual function, cognition, sleep. The expediency of including in everyday practice innovative drugs with antidepressant and thymostabilizing properties was noted, which allows to significantly improve the safety of treatment in accordance with modern world standards while maintaining the effectiveness of treatment of affective disorders.

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