Abnormal uterine bleeding: modern analysis of etiopathogenesis, diagnosis and treatment

August 17, 2021
1343
Resume

The article presents a modern analysis of the etiopathogenesis of abnormal uterine bleeding, a review of scientific studies covering the symptoms, methods of diagnosis and recommendations for the choice of tactics and treatment of abnormal uterine bleeding.

References:

  • 1. Sun Y., Wang Y., Mao L. et al. (2018) Prevalence of abnormal uterine bleeding according to new International Federation of Gynecology and Obstetrics classification in Chinese women of reproductive age: a cross-sectional study. Medicine, 97(31): e11457. doi:10.1097/MD.0000000000011457.
  • 2. Davis E, Sparzak P.B. (2021) Abnormal Uterine Bleeding. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 30422508. https://www.ncbi.nlm.nih.gov/pubmed/30422508
  • 3. Elmaoğulları S., Aycan Z. (2018) Abnormal Uterine Bleeding in Adolescents. J. Clin. Res. Pediatr. Endocrinol., 10(3): 191–197. doi:10.4274/jcrpe.0014.
  • 4. Chodankar R., Critchley H.O. (2019) Abnormal uterine bleeding (including PALM COEIN classification). Obstet. Gynaecol. Reproduct. Med., 29(4): 98–104. doi:10.1016/j.ogrm.2019.01.009
  • 5. Cheong Y., Cameron I.T., Critchley H.O. (2017) Abnormal uterine bleeding. Br. Med. Bull., 123(1): 103–114. doi:10.1093/bmb/ldx027.
  • 6. Chernukha G.E., Ivanov I.A., Efendieva Z.N. et al. (2018) Etiological structure and diagnostic possibilities of abnormal uterine bleeding. Gynecology, 20(2). doi:10.26442/2079-5696_2018.2.14-18 (In Rus.).
  • 7. Levy-Zauberman Y., Pourcelot A.G., Capmas P., Fernandez H. (2017) Update on the management of abnormal uterine bleeding. J. Gynecol. Obstet. Human Reproducti., 46(8): 613–622. doi:10.1016/j.jogoh.2017.07.005.
  • 8. Munro M.G., Critchley H.O., Fraser I.S. (2018) The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int. J. Gynecol. Obstet., 143: 393–408. doi:10.1002/ijgo.12666.
  • 9. Sun Y., Wang Y., Mao L. et al. (2018) Prevalence of abnormal uterine bleeding according to new International Federation of Gynecology and Obstetrics classification in Chinese women of reproductive age: a cross-sectional study. Medicine, 97(31). doi:10.1097/MD.0000000000011457.
  • 10. Chechulina O.V., Kurmanbaev T.E., Tukhvatullina L.M. et al. (2019) Disorders of the hemostatic system as the main pathogenetic mechanism in the occurrence of abnormal uterine bleeding in the postmenopausal period. Kazan Med. J., 100(4). doi: 10.17816/KMJ2019-589 (In Rus.).
  • 11. Giannella L., Cerami L.B., Setti T. et al. (2019) Prediction of endometrial hyperplasia and cancer among premenopausal women with abnormal uterine bleeding. BioMed Res. Int., Article ID 8598152. doi:10.1155/2019/8598152.
  • 12. Chen Y.Y., Tsai C.C., Kung F.T. et al. (2019) Association between hysteroscopic findings of previous cesarean delivery scar defects and abnormal uterine bleeding. Taiwanese J. Obstetr. Gynecol., 58(4): 541–544. doi:10.1016/j.tjog.2019.05.020.
  • 13. Wang L., Guan H.Y., Xia H.X. et al. (2020) Dydrogesterone treatment for menstrual-cycle regularization in abnormal uterine bleeding–ovulation dysfunction patients. World J. Clin. Cases, 8(15): 3259. doi:10.12998/wjcc.v8.i15.3259.
  • 14. Jewson M., Purohit P., Lumsden M.A. (2020) Progesterone and abnormal uterine bleeding/menstrual disorders. Best Pract. Res. Clin. Obstetr. Gynaecol. doi:10.1016/j.bpobgyn.2020.05.004.
  • 15. Singh S., Best C., Dunn S. et al. (2018) Abnormal uterine bleeding in pre-menopausal women. J. Obstetr. Gynaecol. Canada, 40(5): e391–e415. doi:10.1016/j.jogc.2018.03.007.
  • 16. Marnach M.L., Laughlin-Tommaso S.K. (2019) Evaluation and management of abnormal uterine bleeding. Mayo Clin. Proceed., 94(2): 326–335. doi:10.1016/j.mayocp.2018.12.012.
  • 17. Benetti-Pinto C.L., Rosa-e-Silva A.C.J.D.S., Yela D.A., Soares Júnior J.M. (2017) Abnormal uterine bleeding. Revista Brasileira de Ginecologia e Obstetrícia, 39(7): 358–368. doi:10.1055/s-0037-1603807.
  • 18. Alieva D.A., Askarova Z.Z., Karimova G.S. (2020) The value of hysteroscopy in the diagnosis of abnormal uterine bleeding in perimenopause. Sci. Ed. Is., 37 (121). (In Rus.).
  • 19. Ashrafyan L.A., Antonova I.B., Ivashina S.V. et al. (2019) Optimization of diagnostic tactics in patients with abnormal uterine bleeding during peri- and postmenopausal periods. Obstetrics and gynecology: opinion news, training, 7(1): 24–30. doi:10.24411/2303-9698-2019-11003. (In Rus.).
  • 20. Singh P. (2018) Abnormal Uterine Bleeding — evaluation by Endometrial Aspiration. J. Mid-life Health, 9(1): 32–35. doi:10.4103/jmh.JMH_109_17.
  • 21. Narice B.F., Delaney B. Dickson J.M. (2018) Endometrial sampling in low-risk patients with abnormal uterine bleeding: a systematic review and meta-synthesis. BMC Fam. Pract .,19: 135. doi:10.1186/s12875-018-0817-3.
  • 22. Pennant M.E., Mehta R., Moody P. et al. (2017) Premenopausal abnormal uterine bleeding and risk of endometrial cancer. BJOG,124: 404– 411. doi:10.1111/1471-0528.14385.
  • 23. Ilavarasi C.R., Jyothi G.S., Alva N.K. (2019) Study of the efficacy of pipelle biopsy technique to diagnose endometrial diseases in abnormal uterine bleeding. J. Mid-life health, 10(2): 75. doi:10.4103/jmh.JMH_109_18.
  • 24. Kolhe S. (2018) Management of abnormal uterine bleeding — focus on ambulatory hysteroscopy. Int. J. Women’s health, 10: 127. doi:10.2147/IJWH.S98579.
  • 25. Dobrokhotova Yu.E., Saprykina L.V., Filatova L.A., Narimanova M.R. (2020) Abnormal uterine bleeding: management algorithms, therapy methods. RМJ. Mother and child, 3(1). doi:10.32364/2618-8430-2020-3-1-55-60 (In Rus.).
  • 26. Chernukha G.E., Ilyina L.M., Ivanov I.A. (2018) Abnormal uterine bleeding: diagnosis and treatment. Gynecology, 20(4). doi:10.26442/2079-5696_2018.4.4-8 (In Rus.).
  • 27. Clark T.J., Stevenson H. (2017) Endometrial Polyps and Abnormal Uterine Bleeding (AUB-P): What is the relationship, how are they diagnosed and how are they treated? Best Pract. Res. Clin. Obstetr. Gynaecol., 40: 89–104. doi:10.1016/j.bpobgyn.2016.09.005.
  • 28. Wouk N., Helton M. (2019) Abnormal uterine bleeding in premenopausal women. Am. Fam. Phys., 99(7): 435–443. https://www.aafp.org/afp/2019/0401/p435.html.
  • 29. Ouassou K., Klingelhöfer D., Brüggmann D. (2020) Endometriumkarzinom. Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie, 1–5. doi:10.1007/s40664-020-00395-6
  • 30. Kumar N.U., Sridhar M.G., Srilatha K., Habebullah S. (2018) CA 125 is a better marker to differentiate endometrial cancer and abnormal uterine bleeding. Afr. Health Sci., 18(4): 972–978. doi:10.4314/ahs.v18i4.17.
  • 31. Ash S.J., Farrell S.A., Flowerdew G. (1996) Endometrial biopsy in DUB. J. Reprod. Med., 41: 892–896. https://europepmc.org/article/med/8979202.
  • 32. Pestrikova T.Yu., Yurasova E.A., Yurasov I.V., Sukhonosova Yе.L. (2017) Possibilities of drug therapy with a combined oral contraceptive containing estradiol valerate and dienogest for heavy uterine bleeding (literature review). Reproduction problems, 23(6): 34–38. doi:10.17116/repro201723634-38 (In Rus.).
  • 33. Römer T. (2017) Blutungsstörungen unter menopausaler Hormontherapie. Gynäkologe, 50: 599–605. doi:10.1007/s00129-017-4103-6.
  • 34. Rukhlyada N.N., Krylov K.Yu., Biryukova E.I., Novikov E.I. (2017) Pharmacological treatments for abnormal uterine bleeding. Medical alphabet, 1(5): 45–48. https://www.med-alphabet.com/jour/article/view/63 (In Rus.).
  • 35. Bedei I., Delisle B. (2017) Zyklusstörungen in der Adoleszenz. Monatsschrift Kinderheilkunde, 165(10): 858–865. doi:10.1007/s00112-017-0376-z.