Inhibitory and acquired hemophilia: the view of the practitioner

June 25, 2021
852
Resume

The article considers the common and distinctive features of hereditary and acquired hemophilia with a focus on the problem of formation of inhibitors to coagulation factors. Own clinical observations on the successful treatment of patients with inhibitory hemophilia are presented.

References:

  • 1. Averyanov E.V., Semenyaka V.I., Rybakov A.R. (2015) Study of the efficacy of BioClot A in patients with hemophilia A with hemarthrosis of large joints. Hematology. Transfusiology. Eastern Europe, 3: 105–111. (In Rus.).
  • 2. Collins P., Baudo F., Huth-Kühne A. et al. (2010) Consensus recommendations for the diagnosis and treatment of acquired hemophilia A. BMC Res. Notes, Jun. 7.
  • 3. Collins P.W., Hirsch S., Baglin T. et al. (2007) Acquired haemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors’ Organistaion. Blood, 109(5): 1870-7.
  • 4. Teitel J., Berntorp E., Collins P. et al. (2007) A systematic approach to controlling problem bleeds in patients with severe congenital haemophilia A and high-titre inhibitors. Haemophilia, 13(3): 256–263.
  • 5. Wight J., Paisley S. (2003) The epidemiology of inhibitors in haemophilia A: a systematic review. Haemophilia, 9(4): 418–435.
  • 6. Vydyborets S.V., Derpak Yu.Yu., Popovich Yu.Yu. (2018) Hemophilia. Fam. Med., 6(80): 61–66. (In Ukr.).
  • 7. DiMichele D. M., Hoots W. K., Pipe S. W. et al. (2007) International workshop on immune tolerance induction: consensus recommendations. Haemophilia, 13(1): 1–22. doi: 10.1111/j.1365-2516.2007.01497.x.
  • 8. Astermark J. (2015) FVIII inhibitors: pathogenesis and avoidance. Blood; 125(13): 2045–2051. doi: 10.1182/blood-2014-08-535328.
  • 9. Yee T.T., Taher A., Pasi K.J. et al. (2000) A survey of patients with acquired haemophilia in a haemophilia centre over a 28-year period. Clin. Lab. Haematol., 22(5): 275–278.
  • 10. Collins P.W., Hirsch S., Baglin T. et al. (2007) Acquired haemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors’ Organistaion. Blood, 109(5): 1870–1877.
  • 11. Ma A.D., Carrizosa D. (2006) Acquired factor VIII inhibitors: pathophysiology and treatment. Hematology Am. Soc. Hematol. Educ. Program, 432–437.
  • 12. Srivastava A., Santagostino E., Dougall A. et al. (2020) WFH Guidelines for the Management of Hemophilia, 3rd edition. Haemophilia, 26(6): 1–158. doi: 10.1111/hae.14046.
  • 13. Huth-Kühne A., Baudo F., Collins P. et al. (2009) International recommendations on the diagnosis and treatment of patients with acquired haemophilia. Haematologica, 94(4): 566–575.
  • 14. Barlamov P.N., Shchekotov V.V.1, Shutylev A.A. et al. (2015) Postpartum acquired hemophilia. Klin. Med., 93(10): 67–71. (in Rus.).
  • 15. Svirin P.V., Larina L.E. (2009) Acquired hemophilia. Med. Council, 4: 57–61. (In Rus.).
  • 16. Knoebl P., Marco P., Baudo F. et al. (2012) Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2). J. Thromb. Haemost., 10(4): 622–631. doi: 10.1111/j.1538-7836.2012.04654.x.
  • 17. Baudo F., Collins P., Huth-Kühne A. et al. (2012) Management of bleeding in acquired hemophilia A: results from the European Acquired Haemophilia (EACH2) Registry. Blood, 120(1): 39–46. doi: 10.1182/blood-2012-02-408930.
  • 18. Zeitler H., Ulrich-Merzenich G., Goldmann G. et al. (2010) The relevance of the bleeding severity in the treatment of acquired haemophilia — an update of a single-centre experience with 67 patients. Haemophilia,16(102): 95–101. doi: 10.1111/j.1365-2516.2008.01922.x.
  • 19. Wight J., Paisley S. (2003) The epidemiology of inhibitors in haemophilia A: a systematic review. Haemophilia, 9: 418–435.
  • 20. Pardos-Gea J., Fernández-Díaz N., Parra R. et al. (2018) Diagnostic delay in acquired haemophilia: Analysis of causes and consequences in a 20-year Spanish cohort. Haemophilia, 24(3): e163–e166.
  • 21. Wagenman B.L., Townsend K.T., Mathew P. et al. (2009) The laboratory approach to inherited and acquired coagulation factor deficiencies. Clin. Lab. Med., 29: 229–252.
  • 22. Tiede A., Collins P., Knoebl P. et al. (2020) International recommendations on the diagnosis and treatment of acquired hemophilia A. Haematologica, 105(7): 1791–1801.