Epidemiological assessment of nasal carriage of <em>Staphylococcus aureus</em> among patients for whom dental implantation is planned | Ukrainian Medical Journal

Objective: epidemiological assessment of Staphylococcus aureus (S. aureus) carriers in patients with chronic sinusitis who are scheduled for dental implantation.

Object and methods of research. We examined 218 people aged 21 to 60 years (98 men, 120 women) who had various forms of chronic sinusitis (163 — with polyposis, 55 — without polyposis) and who planned dental implantation. Isolation of cultures of microorganisms and their identification was carried out using routine methods based on current regulations. Sensitivity to antibiotics was determined by disco-diffusion method.

Results. It was found that the middle nasal passage of patients with chronic rhinosinusitis, who planned dental implantation, were colonized by various microorganisms. The most commonly isolated bacteria were S. aureus (39.7%). S. epidermidis (17%) and Streptococcus spp. (10.3%). No differences in the level of detection of bacteria on the criteria of atopy, asthma or current status of the smoker were found. Patients with chronic rhinosinusitis without nasal polyps showed a significantly higher rate of detection of various bacteria than patients with polyps. The frequency of isolation of individual bacteria between patients with chronic rhinosinusitis without polyps and with nasal polyps differed. S. aureus and S. epidermidis were more common in patients with chronic rhinosinusitis with polyps, while Enterococcus faecalis and Streptococcus spp. — in patients without nasal polyps. S. aureus strains were most sensitive to gentamicin, ciprofloxacin, ofloxacin, levofloxacin, cefazolin and cefuroxime, and the least sensitive to ampicillin, clarithromycin and erythromycin. Methicillin-resistant strains of S. aureus accounted for 21% of the total number of staphylococci isolated from patients.

Conclusion. Chronic rhinosinusitis and carriers of S. aureus, in particular methicillin-resistant S. aureus in the nasal cavity — is a common problem often faced by patients who are shown dental implantation. When developing measures for the prevention and effective treatment of bacterial complications of dental implantation, it is necessary to take into account the data on microbial pathogens secreted in patients with chronic rhinosinusitis, and their possible resistance to antibiotics.

References:

1. Smith K.A., Orlandi R.R., Rudmic L. (2015) Cost of Adult Chronic Rhinosinusitis: A Systematic Review. The Laryngoscope, 125(7). DOI:10.1002/lary.25180.
2. Malanchuk V.O., Grabovy O.M., Zhukovtseva O.I. (2015) Comparative analysis of biocompatibility of biomorphic ceramics based on silicon carbide and medical titanium: an experimental study. Bull. Probl. Biol. Med., 2(3): 166–169. (In Ukr.).
3. Rasouli R., Barhoum A., Uludag H. (2018) A review of nanostructured surfaces and materials for dental implants: surface coating, patterning and functionalization for improved performance. Biomater. Sci., 6(6): 1312–1338. doi: 10.1039/c8bm00021b. PMID: 29744496.
4. Camps-Font O., Figueiredo R., Valmaseda-Castellón E., Gay-Escoda C. (2015) Postoperative Infections After Dental Implant Placement: Prevalence, Clinical Features, and Treatment. Implant. Dent., 24(6): 713–719. doi: 10.1097/ID.0000000000000325. PMID: 26384096.
5. Cincik H., Ferguson B.J. (2006) The impact of endoscopic cultures on care in rhinosinusitis. Laryngoscope, 116(9): 1562–1568. doi: 10.1097/01.mlg.0000230402.66579.07.
6. Vickery T.W., Ramakrishnan V.R., Suh J.D. (2019) The Role of Staphylococcus aureus in Patients with Chronic Sinusitis and Nasal Polyposis. Curr. Allergy Asthma Rep., 19(4): 21. doi: 10.1007/s11882-019-0853-7.
7. Kim D., Assiri A.M., Kim J.H. (2019) Recent Trends in Bacteriology of Adult Patients with Chronic Rhinosinusitis. J. Clin. Med., 8(11): 1889. doi: 10.3390/jcm8111889.
8. Minukhin VV, Kovalenko NI, Tkachenko VL etc. (2015) Normal nasopharyngeal microflora as a reservoir of multidrug-resistant strains of pathogens of upper respiratory tract infections. Annals of the Mechnikov Institute, 2: 195–199. (In Ukr.).
9. Korenyuk E.S. (2018) Disorders of the respiratory tract microbiota in children with respiratory diseases (literature review). Child health, 13(5): 506–515. (In Rus.).
10. Manes R.P., Batra P.S. (2012) Bacteriology and Antibiotic Resistance in Chronic Rhinosinusitis. Facial Plast. Surg. Clin. North Am., 20(1): 87–91. doi: 10.1016/j.fsc.2011.10.010.
11. Fokkens W.J., Lund V.J., Mullol J. et al. (2012) European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol. Suppl. 23: 1–298.
12. Thanasumpun T., Batra P.S. (2015) Endoscopically-derived bacterial cultures in chronic rhinosinusitis: A systematic review. Am. J. Otolaryngol., 36: 686–691. doi: 10.1016/j.amjoto.2015.04.010.
13. Wei H.Z., Li Y.C., Wang X.D. et al. (2018) The microbiology of chronic rhinosinusitis with and without nasal polyps. Eur. Arch. Otorhinolaryngol., 275: 1439–1447. doi: 10.1007/s00405-018-4931-6.
14. Brook I. (2006) Bacteriology of chronic sinusitis and acute exacerbation of chronic sinusitis. Arch. Otolaryngol. Head Neck Surg., 132: 1099–1101. doi: 10.1001/archotol.132.10.1099.
15. Niederfuhr A., Kirsche H., Riechelmann H., Wellinghausen N. (2009) The bacteriology of chronic rhinosinusitis with and without nasal polyps. Arch. Otolaryngol. Head Neck Surg., 135: 131–136. doi: 10.1001/archoto.2008.531.
16. Kim H.J., Lee K., Yoo J.B. et al. (2006) Bacteriological findings and antimicrobial susceptibility in chronic sinusitis with nasal polyp. Acta Otolaryngol., 126: 489–497.
17. Lee C.W., Lee B.J., Yoo S.H., Yi J.S. (2014) Relationship between positive bacterial culture in maxillary sinus and surgical outcomes in chronic rhinosinusitis with nasal polyps. Auris. Nasus Larynx, 41: 446–449. doi: 10.1016/j.anl.2014.05.010.
18. Liu Q., Lu X., Bo M. et al. (2014) The microbiology of chronic rhinosinusitis with and without nasal polyps. Acta Otolaryngologica, 134(12): 1251–1258. doi: 10.3109/00016489.2013.879737.
19. Safier Frenkel T., Evans D.D. (2020) Are Antibiotics Useful in Acute Chronic Obstructive Pulmonary Disease Exacerbations? Implications for APRN Practice. Advanced Emerg. Nursing J., 42(3): 164–169. doi: 10.1097/TME.0000000000000313.