Evaluation of the lipoprotein profile in stroke patients in different disease phases

December 28, 2020

Aim — to evaluate the lipid profile in patients with cerebral stroke (CS) and its associations with clinical and demographic characteristics, vascular risk factors, stroke phase and global outcome.

Material and methods. In 502 patients (43.0% women), admitted in 2010 through 2018 in various stroke phases (from hyperacute to chronic), baseline levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were directly assessed, then non-HDL-C levels were calculated. Qualitative variables are expressed as numbers and percentages, quantitative variables are presented using the median and interquartile range.

Results. 428 (85.2%) participants were diagnosed with ischemic stroke (IS), 74 (14.8%) with intracerebral hemorrhage. Higher levels of TC, LDL-C, and non-HDL-C were significantly (p<0.05) associated with lacunar and other/undetermined subtypes of IS, obesity, and no history of atrial fibrillation, stroke, or diabetes mellitus. Among 137 patients admitted after 30 days from the index IS, 115 (83.9%) had elevated LDL-C, 116 (84.7%) had elevated non-HDL-C, and 94 (68.5%) had a low level of HDL-C levels.

Conclusions. Elevated levels of atherogenic lipoproteins documented in the majority of patients admitted with subacute or chronic IS point to unmet needs in secondary prevention.


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