Correlations of bioelectrical brain activity spectral analysis parameters with clinical and neurovisualization data in acute period of spontaneous supratentorial intracerebral hemorrhage

September 2, 2020
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Aim of the study: to investigate correlations of bioelectrical brain activity spectral analysis parameters with clinical and neurovisualization data in acute period of spontaneous supratentorial intracerebral hemorrhage (SSICH). Objects and methods. The prospective cohort study of 156 patients (middle age 66.7±0.8 years) in acute period of SSICH was made against the conservative therapy. Neurological examination contained evaluation by Full Outline of UnResponsiveness (FOUR), National Institute of Health Stroke Scale (NIHSS). Acute period of SSICH outcome was evaluated on 21st day after disease onset according to modified Rankin Scale (mRS). The intracerebral hemorrhage volume (ICHV) and midline shift were detected by using computed tomography. Bioelectrical brain activity was done during first 48 hours from the onset of the disease. Spearman correlation coefficient was calculated to estimate the connection between electroencephalographic parameters and clinical, neurovisualization data. Results. It was detected, that relative spectral rhythm power (RSRP) of delta band of both hemispheres has middle strength correlations with ICHV (R=0.69 for affected hemisphere (AH), p<0.05, R=0.67 for intact hemisphere (IH), p<0.05), MS (R=0.62–0,65 for both hemispheres, p<0.05), strong correlations with FOUR score (R=–0.70 for AH, p<0.05, R=–0.72 for IH, p<0.05), NIHSS score (R=0.76 for AH, p<0.05, R=0.74 for IH, p<0.05) at the time of EEG and with mRS score on 21st day of the disease (R=0.84 for both hemispheres, p<0.05). Nevertheless, RSRP of alpha band correlations strength was similar to RSRP of delta band. Fronto-occipital rhythm gradient (FORG) of alpha band of IH correlates with ICHV (R=0.38, p<0.05), MS (R=0.39, p<0.05), FOUR (R=–0.35, p<0.05), NIHSS (R=0.46, p<0.05) and mRS (R=0.44, p<0.05). Thus, total interhemispheric rhythm asymmetry has weak correlation with ICHV (R=–0.18, p<0.05). Conclusions. Elevation of RSRP of delta band on the ground of reduction of RSRP and FORG of alpha band in both hemispheres, decreasing of total spectral rhythm power of AH in comparison with IH during first 48 hours from the onset of SSICH were associated with larger ICHV, more severe MS, neurologic deficit and worse outcome.

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