Damage of jejunum as a possible reason for the development of acute respiratory distress syndrome in COVID-19

August 20, 2020
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An actual and poorly studied question about COVID-19 is the morphological picture of pathological changes of the gastrointestinal tract. Based on the pathomorphological study of four deceased patients with COVID-19 and published data, it was concluded that an important factor in the development of severe and extreme severe cases of COVID-19 may also damage jejunum in combination with diseases that contribute to the development of portopulmonary hypertension.

Published: 20.08.2020

 

References:

  • Ahmetzyanova E.H., Gaynitdinova V.V., Gabdrahimova Z.G., Gareeva G.I. (2010) Legochnaya arterialnaya gipertenziya i zabolevaniya pecheni. Ros. kardiol. zhurn., 6: 61–63.
  • Zayratyants O.V., Camsonova M.V., Mihaleva L.M. i dr. (2020) Patologicheskaya anatomiya COVID-19. NIIOZMM DZM, Moskva, 140
  • Kalacheva T.P., Chernyavskaya G.M., Beloborodova E.I. (2009) Formirovanie legochnoy gipertenzii u bolnyih tsirrozom pecheni. Byul. sib. med., 4: 45–48.
  • Suhov M.N., Belokrinitskaya I.E., Sobakinskih T.V. (2010) Vnepechenochnaya portalnaya gipertenziya u bolnyih s kardiovaskulyarnoy patologiey. Detskaya bolnitsa, 2: 12–18
  • Chan J.F., Yuan S., Kok K.H. et al. (2020) A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet, 395: 514–523.
  • Ellul M.A., Benjamin L. , Singh B. et al. (2020) Neurological associations of COVID-19 The Lancet Neurol. Online ahead of print, July 2. doi:10.1016/ S1474-4422(20)30221-0.
  • Krowka M.J., Wiseman G.A., Burnett O.L. et al. (2000) Hepatopulmonary syndrome: a prospective study of relationships between severity of liver disease, PaO2 response to 100% oxygen, and brain uptake after (99m)Tc MAA lung scanning. Chest, 118: 615–624.
  • Mao R., Qiu Y., He J.-Sh. et al. (2020) Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis. Lancet Gastroenterol. Hepatol. doi:10.1016/S2468-1253(20)30126-6.
  • Peiris J.S., Chu C.M., Cheng V.C. et al. (2003) Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet, 361: 1767–1772.
  • WHO (2020) Clinical care for severe acute respiratory infection: toolkit. COVID-19 adaptation (WHO/2019-nCoV/SARI_toolkit/2020.1).
  • Xu L., Liu J., Lu M. et al. (2020) Liver injury during highly pathogenic human coronavirus infections. Liver Int., 40(5): 998–1004. doi: 10.1111/liv.14435.
  • Ye Q., Wang B., Mao J. et al. (2020) The pathogenesis and treatment of the «Cytokine Storm» in COVID-19. J. Infect., Apr. 10. doi: 10.1016/j.jinf.2020.03.037.